{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:40:07Z","timestamp":1756309207854,"version":"3.44.0"},"reference-count":9,"publisher":"BMJ","issue":"9","funder":[{"DOI":"10.13039\/100010526","name":"NHS Greater Glasgow and Clyde","doi-asserted-by":"publisher","award":["421784","Library Network"],"award-info":[{"award-number":["421784","Library Network"]}],"id":[{"id":"10.13039\/100010526","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,8,20]]},"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>A relatively healthy male patient in his 60s presented with chest pain and shortness of breath in addition to a history of significant weight loss over the preceding months. He was admitted to the hospital and investigated with a CT pulmonary angiogram, which did not demonstrate a pulmonary embolus, but he subsequently went on to have an ultrasound and CT scan because of abnormal findings. His CT demonstrated some thickening of the mid-transverse colon, and, in addition, large volume liver metastases described as innumerable and probably replacing most of the liver.<\/jats:p>\n               <jats:p>Initially, his liver function tests were only mildly deranged at the presentation. Flexible sigmoidoscopy was performed, and a transverse colonic malignancy was identified and biopsied, which demonstrated an extrapulmonary small cell carcinoma (EPSCC). He was admitted for urgent chemotherapy for newly diagnosed metastatic small-cell colonic cancer; he developed tumour lysis syndrome following his first dose of chemotherapy. He continued to decline following this and died soon after his admission. Metastatic small-cell colonic cancer is a rare diagnosis which is challenging to manage due to the lack of trial evidence to drive treatment strategies. The management largely follows the pulmonary small cell cancer pathway. We, therefore, present a colonic EPSCC case outlining the diagnostic and treatment strategies for this disease.<\/jats:p>","DOI":"10.1136\/bcr-2024-260555","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T03:02:35Z","timestamp":1725505355000},"page":"e260555","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Small cell colorectal cancer: a rare tumour with an aggressive course"],"prefix":"10.1136","volume":"17","author":[{"given":"Timothy","family":"Mitchell","sequence":"first","affiliation":[{"name":"Oncology, Beatson West of Scotland Cancer Centre, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alistair","family":"Geraghty","sequence":"additional","affiliation":[{"name":"NHS Forth Valley, Stirling, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Gardner","sequence":"additional","affiliation":[{"name":"NHS Forth Valley, Stirling, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Rodgers","sequence":"additional","affiliation":[{"name":"Oncology, Beatson West of Scotland Cancer Centre, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"2025082708015595000_17.9.e260555.1","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2021-244108","article-title":"Small cell rectal cancer: a therapeutic challenge","volume":"14","author":"Fitzhugh","year":"2021","journal-title":"BMJ Case Rep"},{"key":"2025082708015595000_17.9.e260555.2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.09.075"},{"key":"2025082708015595000_17.9.e260555.3","first-page":"1713","article-title":"Small Cell Carcinoma of the Colon Arising in a Carcinoid Tumor","volume":"33","author":"Saif","year":"2013","journal-title":"Anticancer Res"},{"key":"2025082708015595000_17.9.e260555.4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1752-1947-7-74","article-title":"Advanced small-cell colon carcinoma: a case report","volume":"7","author":"Iwase","year":"2013","journal-title":"J Med Case Reports"},{"key":"2025082708015595000_17.9.e260555.5","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/sj.bjc.6601758","article-title":"Small-cell carcinoma of the gastrointestinal tract: a retrospective study of 64 cases","volume":"90","author":"Brenner","year":"2004","journal-title":"Br J Cancer"},{"key":"2025082708015595000_17.9.e260555.6","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-2-35"},{"key":"2025082708015595000_17.9.e260555.7","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1365-2559.1990.tb01139.x","article-title":"Small cell undifferentiated ('neuroendocrine\u2019) carcinoma of the colon","volume":"16","author":"Sarsfield","year":"1990","journal-title":"Histopathology"},{"key":"2025082708015595000_17.9.e260555.8","doi-asserted-by":"crossref","unstructured":"Elias AW , Colibaseanu DT , Croome KP . 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J Surg Case Rep 2017;2017. doi:10.1093\/jscr\/rjx201","DOI":"10.1093\/jscr\/rjx201"},{"key":"2025082708015595000_17.9.e260555.9","doi-asserted-by":"crossref","first-page":"S169","DOI":"10.1007\/s12032-010-9674-1","article-title":"High-grade neuroendocrine carcinoma of the colon, long-term survival in advanced disease","volume":"28 Suppl 1","author":"Power","year":"2011","journal-title":"Med Oncol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-260555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:02:02Z","timestamp":1756306922000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-260555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":9,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,9,4]]},"published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1136\/bcr-2024-260555"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-260555","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2024,9]]}}}