{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:08:27Z","timestamp":1773137307710,"version":"3.50.1"},"reference-count":16,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,6,15]]},"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>Autoimmune haemolytic anaemia (AIHA), autoimmune destruction of erythrocytes is most commonly secondary to immunomodulated conditions. The association between AIHA and inflammatory bowel disease (IBD) has been poorly investigated. We aim to report a case of AIHA in a patient with ulcerative colitis (UC) treated with vedolizumab.<\/jats:p>\n               <jats:p>A case of a woman in her 30s with UC that after the initiation of vedolizumab developed severe anaemia. Due to the absence of visible blood losses and a positive Coombs direct test, the diagnosis of AIHA was established. The patient initially initiated prednisolone with no response. Rituximab had to be introduced. After a few days with this therapy, there was a clinical and analytical improvement.<\/jats:p>\n               <jats:p>AIHA must be taken into account as a possible cause of anaemia in patients with IBD. The differential diagnosis between IBD or drug-related (namely vedolizumab) as the cause of the AIHA is complex and almost impossible to establish.<\/jats:p>","DOI":"10.1136\/bcr-2024-260586","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T22:45:44Z","timestamp":1719441944000},"page":"e260586","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Case of autoimmune haemolytic anaemia, possibly secondary to vedolizumab in ulcerative colitis, successfully treated with rituximab"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0283-8507","authenticated-orcid":false,"given":"Maria Jos\u00e9","family":"Temido","sequence":"first","affiliation":[{"name":"Gastroenterology, Unidade Local de Sa\u00fade de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Lopes","sequence":"additional","affiliation":[{"name":"Gastroenterology, Unidade Local de Sa\u00fade de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Gastroenterology, Unidade Local de Sa\u00fade de Coimbra, Coimbra, Portugal"},{"name":"Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Portela","sequence":"additional","affiliation":[{"name":"Gastroenterology, Unidade Local de Sa\u00fade de Coimbra, Coimbra, Portugal"},{"name":"Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"2025082709094663000_17.6.e260586.1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.hoc.2015.01.001","article-title":"Warm autoimmune hemolytic anemia","volume":"29","author":"Naik","year":"2015","journal-title":"Hematol\/Oncol Clin N Am"},{"key":"2025082709094663000_17.6.e260586.2","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.3748\/wjg.15.4659","article-title":"Anemia and inflammatory bowel diseases","volume":"15","author":"Gomoll\u00f3n","year":"2009","journal-title":"WJG"},{"key":"2025082709094663000_17.6.e260586.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2016.12.006"},{"key":"2025082709094663000_17.6.e260586.4","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3390\/jcm10030423","article-title":"Diagnosis and management of autoimmune hemolytic anemia in patients with liver and bowel 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J"},{"key":"2025082709094663000_17.6.e260586.9","first-page":"1","article-title":"\u201cHemolytic anemia in inflammatory bowel disease: our \u201cgut\u201d tells us to blame the drug\u201d","volume":"3","author":"Berger","year":"2021","journal-title":"Crohn\u2019s & Colitis 360"},{"key":"2025082709094663000_17.6.e260586.10","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1093\/ibd\/izab090","article-title":"IgA-mediated warm autoimmune hemolytic anemia as an Extraintestinal manifestation in a patient with Crohn disease on vedolizumab","volume":"27","author":"Cheah","year":"2021","journal-title":"Inflamm Bowel Dis"},{"key":"2025082709094663000_17.6.e260586.11","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1159\/000486803","article-title":"Refractory chronic Pouchitis and autoimmune hemolytic anemia successfully treated with vedolizumab","volume":"25","author":"Martins","year":"2018","journal-title":"GE Port J 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