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VBD is characterised by the disruption of smooth muscle atrophy, reticular fibre degeneration and multiple gaps in the inner elastic lamina, causing thinning of the tunica media and arterial wall weakening and deformation. VBD can be asymptomatic. VBD is often characterised by ischaemic stroke, intracerebral haemorrhage, brainstem\/cranial nerve compression and subarachnoid haemorrhage. Vascular events are the most common clinical manifestation. Slow arterial blood flow results in hyperintense vascular signals, which are linked with a larger infarct and a higher risk of cerebral bleeding. Treatment for VBD is difficult. Currently, there are no specific treatments for VBD, and the available treatments focus on the consequences.<\/jats:p>","DOI":"10.1136\/bcr-2024-260606","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T23:20:12Z","timestamp":1729725612000},"page":"e260606","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Hyperintense vessel sign in vertebrobasilar dolichoectasia"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7925-9741","authenticated-orcid":false,"given":"Prashant","family":"Bhatele","sequence":"first","affiliation":[{"name":"Department of Neurology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India-576104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna Ramakrishna","family":"Pai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India-576104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,10,23]]},"reference":[{"key":"2025082709182898000_17.10.e260606.1","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1212\/01.WNL.0000103168.14885.A8","article-title":"Intracranial arterial dolichoectasia and its relation with atherosclerosis and stroke subtype","volume":"61","author":"Pico","year":"2003","journal-title":"Neurology (ECronicon)"},{"key":"2025082709182898000_17.10.e260606.2","first-page":"50","article-title":"Role of perivascular sympathetic nerves in autoregulation of cerebral blood flow and in blood-brain barrier functions","volume":"64","author":"Edvinsson","year":"1977","journal-title":"Acta Neurol Scand Suppl"},{"key":"2025082709182898000_17.10.e260606.3","doi-asserted-by":"publisher","DOI":"10.1159\/000070196"},{"key":"2025082709182898000_17.10.e260606.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05114.x"},{"key":"2025082709182898000_17.10.e260606.5","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.181"},{"key":"2025082709182898000_17.10.e260606.6","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1148\/rg.2016150032","article-title":"Multimodality Imaging of Vertebrobasilar Dolichoectasia: Clinical Presentations and Imaging Spectrum","volume":"36","author":"Samim","year":"2016","journal-title":"Radiographics"},{"key":"2025082709182898000_17.10.e260606.7","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00089-7"},{"key":"2025082709182898000_17.10.e260606.8","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.45.1.29"},{"key":"2025082709182898000_17.10.e260606.9","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.034256"},{"key":"2025082709182898000_17.10.e260606.10","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1111\/jon.12177","article-title":"Fluid Attenuated Inversion Recovery Vascular Hyperintensities Possibly Indicate Slow Arterial Blood Flow in Vertebrobasilar Dolichoectasia","volume":"25","author":"F\u00f6rster","year":"2015","journal-title":"J Neuroimaging"},{"key":"2025082709182898000_17.10.e260606.11","first-page":"55","article-title":"High-resolution computed tomography of the basilar artery: 1. 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