{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:01:34Z","timestamp":1770681694691,"version":"3.49.0"},"reference-count":23,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,5,31]]},"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>Granulomatous amoebic encephalitis due to <jats:italic>Acanthamoeba<\/jats:italic> spp is a rare, near-fatal central nervous system infection. It is often seen in immunocompromised individuals. Here we describe a survivor of this infection who was co-infected with multidrug-resistant tuberculosis. He presented to us with features of meningitis and a history of chronic cough. The chest X-ray was classical for pulmonary tuberculosis. Neuroimaging was suggestive of encephalitis; herpes simplex virus PCR was negative. Cerebrospinal fluid (CSF) showed lymphocytic pleocytosis. Wet mounts revealed trophozoites of <jats:italic>Acanthamoeba<\/jats:italic>. Currently, he is being treated with oral bedaquiline, levofloxacin, linezolid, clofazimine, cycloserine and pyridoxine for tuberculosis. He received intravenous amikacin and oral cotrimoxazole and fluconazole for <jats:italic>Acanthamoeba<\/jats:italic> infection for 1 month. The resolution was confirmed by repeating the CSF wet mount, culture and neuroimaging. He was then discharged with oral rifampicin, cotrimoxazole and fluconazole. He is currently under our close follow-up.<\/jats:p>","DOI":"10.1136\/bcr-2024-260613","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T22:40:52Z","timestamp":1718318452000},"page":"e260613","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Granulomatous amoebic encephalitis due to <i>Acanthamoeba<\/i> spp complicating multidrug-resistant tuberculous meningitis in an immunocompetent individual"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2302-6827","authenticated-orcid":false,"given":"Debasis","family":"Mondal","sequence":"first","affiliation":[{"name":"General Medicine, Medical College, Kolkata, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prantick Kumar","family":"Bhunia","sequence":"additional","affiliation":[{"name":"General Medicine, Medical College, Kolkata, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipamoy","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"General Medicine, Medical College, Kolkata, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashim","family":"Sarkar","sequence":"additional","affiliation":[{"name":"General Medicine, Medical College, Kolkata, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,6,13]]},"reference":[{"key":"2025082803361023000_17.6.e260613.1","unstructured":"tbcindia.gov.in . 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