{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:10:22Z","timestamp":1756361422419,"version":"3.44.0"},"reference-count":17,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"unspecified","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,8,31]]},"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>A male of East Asian background in his 30s presented to the emergency department with acute onset global muscle weakness, elevated creatine kinase, profound hypokalaemia and hyperthyroidism. A diagnosis of thyrotoxic periodic paralysis was made and the myopathy resolved promptly with potassium replacement. However, 3\u2009months after being commenced on carbimazole for hyperthyroidism, the patient developed myalgias without weakness associated with an elevated creatine kinase. The myositis panel was negative, while a muscle biopsy showed nonspecific, mild myopathic changes with minimal lymphocytic inflammation. As a change in therapy from carbimazole to propylthiouracil resulted in prompt symptom improvement and normalisation of serum creatine kinase levels, a presumptive diagnosis of carbimazole-induced myositis was made. Genetic testing for hereditary skeletal muscle channelopathies did not identify any gene of interest.<\/jats:p>","DOI":"10.1136\/bcr-2024-260722","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T13:50:26Z","timestamp":1727185826000},"page":"e260722","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Thyrotoxic periodic paralysis complicated by carbimazole-associated myositis"],"prefix":"10.1136","volume":"17","author":[{"given":"Harsan","family":"Kanagaretnam","sequence":"first","affiliation":[{"name":"Endocrinology, Concord Repatriation General Hospital, Concord, New South Wales, Australia"},{"name":"The University of Sydney Concord Clinical School, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kajanan","family":"Parameshwaran","sequence":"additional","affiliation":[{"name":"Endocrinology, Concord Repatriation General Hospital, Concord, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirtan","family":"Ganda","sequence":"additional","affiliation":[{"name":"Endocrinology, Concord Repatriation General Hospital, Concord, New South Wales, Australia"},{"name":"The University of Sydney Concord Clinical School, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus Joachim","family":"Seibel","sequence":"additional","affiliation":[{"name":"Endocrinology, Concord Repatriation General Hospital, Concord, New South Wales, Australia"},{"name":"The University of Sydney Concord Clinical School, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"2025082722292102000_17.9.e260722.1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1080\/08998280.2006.11928143","article-title":"Thyrotoxic periodic paralysis","volume":"19","author":"Lam","year":"2006","journal-title":"Proc Bayl Univ Med Cent"},{"doi-asserted-by":"publisher","key":"2025082722292102000_17.9.e260722.2","DOI":"10.1530\/EJE-13-0381"},{"doi-asserted-by":"publisher","key":"2025082722292102000_17.9.e260722.3","DOI":"10.1001\/archinte.1997.00440270147014"},{"key":"2025082722292102000_17.9.e260722.4","first-page":"e133","article-title":"Carbimazole-induced myositis in the treatment of Graves\u2019 disease: a complication in genetically susceptible individuals?","volume":"54","author":"Lim","year":"2013","journal-title":"Sing Med J"},{"doi-asserted-by":"publisher","key":"2025082722292102000_17.9.e260722.5","DOI":"10.1681\/ASN.2012010046"},{"doi-asserted-by":"publisher","key":"2025082722292102000_17.9.e260722.6","DOI":"10.1016\/j.cell.2009.12.024"},{"key":"2025082722292102000_17.9.e260722.7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1080\/20009666.2017.1316906","article-title":"Thyrotoxic periodic paralysis: a case study and review of the literature","volume":"7","author":"Meseeha","year":"2017","journal-title":"J Community Hosp Intern Med Perspect"},{"doi-asserted-by":"publisher","key":"2025082722292102000_17.9.e260722.8","DOI":"10.1111\/j.1365-2265.2007.03014.x"},{"doi-asserted-by":"publisher","key":"2025082722292102000_17.9.e260722.9","DOI":"10.1053\/ajkd.2001.22090"},{"key":"2025082722292102000_17.9.e260722.10","article-title":"Thyrotoxic Periodic Paralysis: An Underdiagnosed and Under-recognized Condition","volume":"7","author":"Tella","year":"2015","journal-title":"Cureus"},{"doi-asserted-by":"publisher","key":"2025082722292102000_17.9.e260722.11","DOI":"10.1056\/NEJMcp0801880"},{"key":"2025082722292102000_17.9.e260722.12","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(89)92550-6","article-title":"Myositis in association with carbimazole therapy","volume":"1","author":"Page","year":"1989","journal-title":"Lancet"},{"key":"2025082722292102000_17.9.e260722.13","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/0140-6736(91)91941-M","article-title":"Biopsy-proven myositis with microvasculitis in association with carbimazole","volume":"338","author":"Pasquier","year":"1991","journal-title":"Lancet"},{"key":"2025082722292102000_17.9.e260722.14","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1089\/thy.2009.0014","article-title":"Myositis associated with the decline of thyroid hormone levels in thyrotoxicosis: a syndrome?","volume":"19","author":"Shaheen","year":"2009","journal-title":"Thyroid"},{"doi-asserted-by":"publisher","key":"2025082722292102000_17.9.e260722.15","DOI":"10.1136\/ard.47.4.340"},{"key":"2025082722292102000_17.9.e260722.16","article-title":"Anti-thyroid drugs-related myopathy: is carbimazole the real culprit?","volume":"13","author":"Tsang","year":"2015","journal-title":"Int J Endocrinol Metab"},{"doi-asserted-by":"crossref","unstructured":"O\u2019Donnell N , McCarthy A , Thong K . Carbimazole induced rhabdomyolysis. Endocrinol Diabetes Metab Case Rep 2021;2021. doi:10.1530\/EDM-21-0006","key":"2025082722292102000_17.9.e260722.17","DOI":"10.1530\/EDM-21-0006"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-260722","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T05:29:31Z","timestamp":1756358971000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-260722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":17,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,9,24]]},"published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1136\/bcr-2024-260722"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-260722","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2024,9]]}}}