{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:40:23Z","timestamp":1756374023116,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,5,13]]},"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n                  <jats:italic>Clostridium perfringens<\/jats:italic> is notorious for causing skin and soft tissue infections and food poisoning. Rarely, <jats:italic>C. perfringens<\/jats:italic> infections are associated with severe haemolysis, with a mortality rate of &gt;80%. A previously healthy man in his 70s who presented with fever as his chief symptom was promptly admitted to a regional core hospital. Over the next 3\u2009hours, shock and multiple organ failure ensued, leading to referral to our hospital for intensive care. We suspected a liver abscess caused by <jats:italic>C. perfringens<\/jats:italic> infection with haemolysis, findings of severe haemolysis and a liver mass with gas production that appeared within a few hours. Though surgical drainage was contemplated, low blood pressure resulted in death within 3\u2009hours of arrival at our hospital. The next day, a blood culture confirmed <jats:italic>C. perfringens<\/jats:italic>, proving the diagnosis. Improving patient outcomes requires increased awareness of the disease and early detection.<\/jats:p>","DOI":"10.1136\/bcr-2024-260800","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T23:47:19Z","timestamp":1716421639000},"page":"e260800","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Clostridium perfringens<\/i>-induced liver abscess with severe haemolysis"],"prefix":"10.1136","volume":"17","author":[{"given":"Tomotaka","family":"Takanosu","sequence":"first","affiliation":[{"name":"Emergency Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimitsu","family":"Izawa","sequence":"additional","affiliation":[{"name":"Emergency Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikara","family":"Yonekawa","sequence":"additional","affiliation":[{"name":"Emergency Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Mato","sequence":"additional","affiliation":[{"name":"Emergency Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"2025082802100739000_17.5.e260800.1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1701.P11101"},{"key":"2025082802100739000_17.5.e260800.2","first-page":"343","article-title":"Clostridium Perfringens Septicemia with massive Intravascular Haemolysis: a case report and review of the literature","volume":"68","author":"van Bunderen","year":"2010","journal-title":"Neth J Med"},{"key":"2025082802100739000_17.5.e260800.3","doi-asserted-by":"crossref","DOI":"10.1038\/s41426-018-0144-8","article-title":"An update on the human and animal Enteric pathogen Clostridium Perfringens","volume":"7","author":"Kiu","year":"2018","journal-title":"Emerg Microbes Infect"},{"key":"2025082802100739000_17.5.e260800.4","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.713509","article-title":"Pathogenic characterization of Clostridium Perfringens strains isolated from patients with massive Intravascular hemolysis","volume":"12","author":"Suzaki","year":"2021","journal-title":"Front Microbiol"},{"key":"2025082802100739000_17.5.e260800.5","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.2147\/IDR.S219472","article-title":"Fatal liver infection caused by Clostridium Perfringens after common bile duct Stenting due to Pancreatic cancer: a case report","volume":"12","author":"Xu","year":"2019","journal-title":"Infect Drug Resist"},{"key":"2025082802100739000_17.5.e260800.6","doi-asserted-by":"crossref","unstructured":"Stabler S , Tit\u00e9cat M , Duployez C , et al . 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Massive Haemolysis, gas-forming liver abscess and sepsis due to Clostridium Perfringens Bacteraemia. 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