{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T07:24:16Z","timestamp":1766820256672,"version":"3.44.0"},"reference-count":18,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,8,7]]},"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>A man in his 60s presented to our emergency department with severe peripheral pitting oedema, weight gain, dyspnoea and diarrhoea. Blood tests showed a hypoalbuminaemia of 15\u2009g\/L. A suspicion of protein-losing enteropathy arose after the exclusion of albuminuria, cardiac failure, protein deficiency and liver cirrhosis. An abdominal CT scan revealed a wall thickening of the colon, and a subsequent colonoscopy identified multiple large obstructive polyps in the ascending colon. The patient underwent a right hemicolectomy which revealed the presence of tubulovillous polyps and a pT2N0 colon carcinoma. Following surgery, the patient experienced clinical improvement with normalisation of serum albumin and resolution of the oedema.<\/jats:p>\n               <jats:p>Protein-losing enteropathy should be considered an underlying syndrome in patients with peripheral oedema and hypoalbuminaemia in the absence of cardiac failure, proteinuria, malnutrition and hepatic disease. This diagnostic process requires a multidisciplinary approach. For adequate treatment, the primary cause of protein-losing enteropathy needs to be investigated.<\/jats:p>","DOI":"10.1136\/bcr-2024-261081","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T12:00:26Z","timestamp":1724068826000},"page":"e261081","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Protein-losing enteropathy as a result of colon polyposis and colon cancer: a multidisciplinary approach to diagnosis and treatment"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3284-8773","authenticated-orcid":false,"given":"Hendrien","family":"Kuipers","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Isala Hospital, Zwolle, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henderik L","family":"van Westreenen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Isala Hospital, Zwolle, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Freek C P","family":"Moll","sequence":"additional","affiliation":[{"name":"Department of Pathology, Isala Hospital, Zwolle, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wouter H","family":"de Vos tot Nederveen Cappel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Isala Hospital, Zwolle, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"2025082803502472000_17.8.e261081.1","doi-asserted-by":"crossref","first-page":"S193","DOI":"10.1007\/s11739-012-0802-0","article-title":"Hypoalbuminemia","volume":"7 Suppl 3","author":"Gatta","year":"2012","journal-title":"Intern Emerg Med"},{"key":"2025082803502472000_17.8.e261081.2","unstructured":"Greenwald DA . Protein-losing gastroenteropathy. In: Feldman M , Friedman LS , Brandt LJ , eds. Sleisenger and fordtran\u2019s gastrointestinal and liver disease. 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