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Less common aetiologies, including recent Endoscopic Retrograde Cholangiopancreatography (ERCP) procedure, hypercalcaemia, malignancy, infection and trauma, were also ruled out, making drug-induced acute pancreatitis the most likely aetiology. After consideration of her medication list, doxycycline was determined to be the offending medication. On discontinuation and treatment with fluids and analgesics, her condition slowly improved.<\/jats:p>\n               <jats:p>This case illustrates a rare but severe complication of doxycycline use. Determining the aetiology of drug-induced acute pancreatitis is more difficult in older patients due to high rates of polypharmacy. Recognition of doxycycline as an aetiology of drug-induced pancreatitis may allow earlier recognition and intervention in cases of suspected pancreatitis without a clear common aetiology in older patients with polypharmacy.<\/jats:p>","DOI":"10.1136\/bcr-2024-261364","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T23:00:25Z","timestamp":1726009225000},"page":"e261364","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Doxycycline-associated acute pancreatitis: a rare adverse effect of a commonly prescribed antibiotic"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2224-9264","authenticated-orcid":false,"given":"Melissa Rachel","family":"Goldin","sequence":"first","affiliation":[{"name":"School of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael","family":"Petry","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parul","family":"Goyal","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine and Public Health, Vanderbilt University Medical Center, Nashville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,9,10]]},"reference":[{"key":"2025082711190899000_17.9.e261364.1","doi-asserted-by":"crossref","unstructured":"Mederos MA , Reber HA , Girgis MD . 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