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Immunohistochemistry testing for gross cystic disease fluid protein was positive, and the tumour demonstrated positive oestrogen receptor status, while human epidermal growth factor receptor 2 status was negative. The immunohistochemical profile of this carcinoma was identical to that observed in synchronous breast cores, indicating metastatic invasive lobular carcinoma of the breast.<\/jats:p>\n               <jats:p>This unusual presentation of breast cancer metastasis is not well recognised.<\/jats:p>","DOI":"10.1136\/bcr-2024-261395","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T23:55:38Z","timestamp":1740441338000},"page":"e261395","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Metastatic breast cancer diagnosed on upper gastrointestinal endoscopy"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3831-844X","authenticated-orcid":false,"given":"Annabelle Xiao Hui","family":"LIM","sequence":"first","affiliation":[{"name":"School of Medicine, Cardiff University School of Medicine, Cardiff, UK"},{"name":"University Hospital Llandough, Cardiff and Vale University Health board, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rwth","family":"Ellis-Owen","sequence":"additional","affiliation":[{"name":"Radiology, University Hospital Llandough, Cardiff and Vale University Health board, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meleri","family":"Morgan","sequence":"additional","affiliation":[{"name":"Histopathology, University Hospital Llandough, Cardiff and Vale University Health board, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1666-4536","authenticated-orcid":false,"given":"Badr","family":"Abdalla","sequence":"additional","affiliation":[{"name":"Gastroenterology, University Hospital Llandough, Cardiff and Vale University Health board, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"2025082709140025000_18.2.e261395.1","unstructured":"Cancer Research UK . 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