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The wound swabs identified methicillin-resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) and subsequent identification of the exotoxin Panton-Valentine leukocidin (PVL). Following MRSA decolonisation therapy with mupirocin and octenidine, only one family member has had one recurrence of an SSTI with MRSA isolated from the wound. When patients present with a history of recurrent SSTIs or a family all have had similar presentations, the clinician should consider MRSA with PVL exotoxin infection. Then patients must be referred for confirmation to ensure management is effective for the SSTI and prescribe MRSA decolonisation therapy concurrently to reduce recurrence.<\/jats:p>","DOI":"10.1136\/bcr-2024-261423","type":"journal-article","created":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T04:20:13Z","timestamp":1723868413000},"page":"e261423","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Recurrent skin and soft tissue infections (SSTIs) in three family members caused by methicillin-resistant <i>Staphylococcus aureus<\/i> (MRSA) with Panton-Valentine leukocidin (PVL) exotoxin"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5021-6641","authenticated-orcid":false,"given":"Ashley","family":"Reed","sequence":"first","affiliation":[{"name":"Emergency Department, Southend University Hospital NHS Foundation Trust, Westcliff-on-Sea, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"2025082800562350000_17.8.e261423.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2015.05.007"},{"key":"2025082800562350000_17.8.e261423.2","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp15X686929"},{"key":"2025082800562350000_17.8.e261423.3","unstructured":"NHS Digital . 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