{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T19:41:51Z","timestamp":1784662911034,"version":"3.55.0"},"reference-count":21,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,9,25]]},"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>We present a never-transfused girl with thalassemia intermedia who was admitted for febrile aplastic crisis due to human parvovirus B19. After a first transfusion of packed red blood cells, she developed pulmonary oedema. She improved with supportive care including the use of intravenous diuretics. Due to severe anaemia, she received a second blood transfusion, antibiotics for febrile neutropenia and intravenous \u03b3 globulin for control of the parvovirus infection. She had an uneventful recovery. The first of her male blood donors had an antibody against a patient\u2019s human leukocyte antigens type II antigen with a high mean fluorescent intensity. Our patient had clinical features and supportive laboratory evidence for mild transfusion-related acute lung injury (TRALI). However, she also met the criteria for transfusion-associated circulatory overload (TACO). We conclude that our patient likely suffered from TRALI\/TACO, a consensus term proposed in 2019 for patients in whom TRALI cannot be distinguished from TACO or in whom both conditions occur simultaneously.<\/jats:p>","DOI":"10.1136\/bcr-2024-261488","type":"journal-article","created":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T07:55:40Z","timestamp":1729929340000},"page":"e261488","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Transfusion-related acute lung injury\/transfusion-associated circulatory overload in a child with non-transfusion dependent thalassemia and aplastic crisis due to acute parvovirus B19 infection"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7837-9733","authenticated-orcid":false,"given":"Elpis","family":"Mantadakis","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Democritus University of Thrace, Faculty of Medicine, Alexandroupolis, Thrace, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeliki","family":"Vittoraki","sequence":"additional","affiliation":[{"name":"Department of Immunology and National Tissue Typing Center, G. Gennimatas General Hospital of Athens, Athens, Attika, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Siorenta","sequence":"additional","affiliation":[{"name":"Department of Immunology and National Tissue Typing Center, G. Gennimatas General Hospital of Athens, Athens, Attika, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eftychia","family":"Kontekaki","sequence":"additional","affiliation":[{"name":"Blood Transfusion Center, University General Hospital of Alexandroupolis, Alexandroupolis, Thrace, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,10,26]]},"reference":[{"key":"2025082707590400000_17.10.e261488.1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-10-860809"},{"key":"2025082707590400000_17.10.e261488.2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-338913"},{"key":"2025082707590400000_17.10.e261488.3","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1111\/trf.15311","article-title":"A consensus redefinition of transfusion-related acute lung injury","volume":"59","author":"Vlaar","year":"2019","journal-title":"Transfusion"},{"key":"2025082707590400000_17.10.e261488.4","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2018.1.585"},{"key":"2025082707590400000_17.10.e261488.5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.15.1968"},{"key":"2025082707590400000_17.10.e261488.6","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1111\/j.0041-1132.2004.04193.x","article-title":"Recipients of blood from a donor with multiple HLA antibodies: a lookback study of transfusion-related acute lung injury","volume":"44","author":"Toy","year":"2004","journal-title":"Transfusion"},{"key":"2025082707590400000_17.10.e261488.7","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/ajcp\/aqaa279","article-title":"Transfusion-Associated Circulatory Overload and Transfusion-Related Acute Lung Injury","volume":"156","author":"van den Akker","year":"2021","journal-title":"Am J Clin Pathol"},{"key":"2025082707590400000_17.10.e261488.8","doi-asserted-by":"crossref","first-page":"e350","DOI":"10.1016\/S2352-3026(19)30080-8","article-title":"Revised international surveillance case definition of transfusion-associated circulatory overload: a classification agreement validation study","volume":"6","author":"Wiersum-Osselton","year":"2019","journal-title":"Lancet Haematol"},{"key":"2025082707590400000_17.10.e261488.9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-370932"},{"key":"2025082707590400000_17.10.e261488.10","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-008-9258-4"},{"key":"2025082707590400000_17.10.e261488.11","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.jmii.2019.05.009","article-title":"Human parvovirus B19 infection in patients with or without underlying diseases","volume":"52","author":"Sim","year":"2019","journal-title":"J Microbiol Immunol Infect"},{"key":"2025082707590400000_17.10.e261488.12","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis1046"},{"key":"2025082707590400000_17.10.e261488.13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1998.00364.x"},{"key":"2025082707590400000_17.10.e261488.14","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318186d87b"},{"key":"2025082707590400000_17.10.e261488.15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1537-2995.2008.01941.x","article-title":"The accuracy of natriuretic peptides (brain natriuretic peptide and N-terminal pro-brain natriuretic) in the differentiation between transfusion-related acute lung injury and transfusion-related circulatory overload in the critically ill","volume":"49","author":"Li","year":"2009","journal-title":"Transfusion"},{"key":"2025082707590400000_17.10.e261488.16","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.08829"},{"key":"2025082707590400000_17.10.e261488.17","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/pbc.20779","article-title":"Transfusion related acute lung injury syndrome (TRALI) in a patient with thalassaemia","volume":"46","author":"Koussi","year":"2006","journal-title":"Pediatr Blood Cancer"},{"key":"2025082707590400000_17.10.e261488.18","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-1048.2001.03305.x"},{"key":"2025082707590400000_17.10.e261488.19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01948.x"},{"key":"2025082707590400000_17.10.e261488.20","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1423-0410.2011.01556.x","article-title":"Benefit of transfusion-related acute lung injury risk-minimization measures--German haemovigilance data (2006-2010)","volume":"102","author":"Funk","year":"2012","journal-title":"Vox Sang"},{"key":"2025082707590400000_17.10.e261488.21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2010.01392.x"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-261488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:59:16Z","timestamp":1756306756000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-261488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":21,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10,26]]},"published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1136\/bcr-2024-261488"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-261488","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]}}}