{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:05:15Z","timestamp":1756339515657,"version":"3.44.0"},"reference-count":9,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,2,27]]},"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>Children with sickle cell disease (SCD) may have hepatobiliary pathology secondary to chronic haemolysis and intrahepatic sickling during vaso-occlusive crisis. Choledocholithiasis in children with SCD is usually secondary to cholelithiasis but, less commonly, can be due to primary choledocholithiasis. A known history of cholecystectomy may lead to a delay in diagnosis of biliary tract pathology in sickle cell patients presenting with abdominal pain. Normal conjugated bilirubin levels may further stray healthcare providers away from considering biliary disease in these patients. Here, we report an unusual case of primary choledocholithiasis in a child with SCD after cholecystectomy with normal conjugated bilirubin at the time of presentation.<\/jats:p>","DOI":"10.1136\/bcr-2024-261650","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T15:10:28Z","timestamp":1744816228000},"page":"e261650","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Primary choledocholithiasis after cholecystectomy without hyperbilirubinaemia in a child with sickle cell disease"],"prefix":"10.1136","volume":"18","author":[{"given":"Ashley Inez","family":"Thrower","sequence":"first","affiliation":[{"name":"Internal Medicine and Pediatrics, Duke University, Durham, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Roberts","sequence":"additional","affiliation":[{"name":"Pediatrics, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua P","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno P","family":"Chumpitazi","sequence":"additional","affiliation":[{"name":"Pediatrics, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"2025082708315384000_18.4.e261650.1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.4291\/wjgp.v8.i3.108","article-title":"Acute and chronic hepatobiliary manifestations of sickle cell disease: A review","volume":"8","author":"Shah","year":"2017","journal-title":"World J Gastrointest Pathophysiol"},{"key":"2025082708315384000_18.4.e261650.2","first-page":"1","article-title":"Hepatobiliary Manifestations of Sickle Cell Anemia","volume":"3","author":"Issa","year":"2010","journal-title":"Gastroenterology Res"},{"key":"2025082708315384000_18.4.e261650.3","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2020-319778"},{"key":"2025082708315384000_18.4.e261650.4","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.3390\/jcm8091481","article-title":"Hepatobiliary Complications in Children with Sickle Cell Disease: A Retrospective Review of Medical Records from 616 Patients","volume":"8","author":"Allali","year":"2019","journal-title":"J Clin Med"},{"key":"2025082708315384000_18.4.e261650.5","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jceh.2020.08.003","article-title":"Sickle Hepatopathy","volume":"11","author":"Praharaj","year":"2021","journal-title":"J Clin Exp Hepatol"},{"key":"2025082708315384000_18.4.e261650.6","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/XCS.0000000000000949","article-title":"Early Cholecystectomy in Patients with Sickle Cell Disease with Uncomplicated Cholelithiasis Is Associated with Better Outcomes","volume":"238","author":"Zeineddin","year":"2024","journal-title":"J Am Coll Surg"},{"key":"2025082708315384000_18.4.e261650.7","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0579"},{"key":"2025082708315384000_18.4.e261650.8","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.2169\/internalmedicine.47.1326","article-title":"Multiple primary choledocholithiasis in sickle cell disease","volume":"47","author":"Vicari","year":"2008","journal-title":"Intern Med"},{"key":"2025082708315384000_18.4.e261650.9","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.gie.2021.01.030","article-title":"A prospective multicenter analysis from the Pediatric ERCP Database Initiative: predictors of choledocholithiasis at ERCP in pediatric patients","volume":"94","author":"Fishman","year":"2021","journal-title":"Gastrointest Endosc"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-261650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:32:01Z","timestamp":1756308721000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-261650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":9,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4,16]]},"published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1136\/bcr-2024-261650"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-261650","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2025,4]]}}}