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Surgical management of PJI has increased surgical risks and is costly to the healthcare system. This case study presents a unique clinical scenario involving a patient who was diagnosed with Lyme PJI at the total knee arthroplasty site after undergoing surgical management. Lyme PJI is a rare condition, and there is limited guidance on the diagnosis and management of this condition. It should be considered in the differential of certain individuals with appropriate epidemiological risk factors. This report aims to highlight the complexities associated with the diagnosis and management of periprosthetic Lyme infections.<\/jats:p>","DOI":"10.1136\/bcr-2024-261837","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T09:00:22Z","timestamp":1736326822000},"page":"e261837","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Lyme disease periprosthetic joint infection"],"prefix":"10.1136","volume":"18","author":[{"given":"Theodore","family":"Yang","sequence":"first","affiliation":[{"name":"Medical College of Wisconsin - Central Wisconsin Campus, Wausau, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6634-6272","authenticated-orcid":false,"given":"FNU","family":"Shweta","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Mayo Clinic Health System in Eau Claire, Eau Claire, Wisconsin, 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