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The patient received 30.6\u2009Gy in 17 fractions to the involved sites of disease which led to a marked improvement in liver function, allowing curative intent chemotherapy to be initiated. The patient achieved complete metabolic response and at the most recent follow-up she had no signs of recurrent disease and near-normal liver function tests. This demonstrates that tumour-directed radiotherapy can be used as a potential bridge to curative chemotherapy in early stage HL-associated VBDS.<\/jats:p>","DOI":"10.1136\/bcr-2024-261879","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T13:50:44Z","timestamp":1727185844000},"page":"e261879","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Tumour-directed radiotherapy as a successful bridge to curative chemotherapy in early stage Hodgkin\u2019s lymphoma-associated vanishing bile duct syndrome"],"prefix":"10.1136","volume":"17","author":[{"given":"Alexandra","family":"Knesl","sequence":"first","affiliation":[{"name":"Radiation Oncology, Queensland Health, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Mapp","sequence":"additional","affiliation":[{"name":"Haematology, Queensland Health, Brisbane, Queensland, Australia"},{"name":"Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Tallis","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Queensland Health, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Queensland Health, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"2025082707583407000_17.9.e261879.1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/pro6.1114","article-title":"Hodgkin\u2019s Lymphoma-Associated Vanishing Bile Duct Syndrome Successfully Treated with Radiation as a Bridge to Chemotherapy","volume":"5","author":"Ebadi","year":"2021","journal-title":"Prec Radiat Oncol"},{"key":"2025082707583407000_17.9.e261879.2","doi-asserted-by":"publisher","DOI":"10.1080\/02841860701644078"},{"key":"2025082707583407000_17.9.e261879.3","unstructured":"NSW Government . 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