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After treatment with immunotherapy with high-dose corticosteroids, intravenous immunoglobulins, upfront rituximab and excision of the tumour, the patient gradually recovered. Partial retrograde and anterograde amnesia persisted during the initial weeks, followed by slow and steady improvement. Autoimmune encephalitis is a severe neurological disorder associated with antibodies against neuronal cell-surface or intracellular onconeural proteins. Anti-leucine-rich glioma inactivated 1 (LGI1) predominantly affects males in the seventh decade of life, and less than 10% of all cases are associated with cancer. Paraneoplastic cases have been associated with malignant thymoma, neuroendocrine tumours and mesothelioma and usually had Morvan syndrome, in which serum antibodies are more frequently directed against CASPR2 than against LGI1. We report the first well-documented case of anti-LGI1 limbic encephalitis in a woman with newly diagnosed breast cancer.<\/jats:p>","DOI":"10.1136\/bcr-2024-261902","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T02:31:17Z","timestamp":1743647477000},"page":"e261902","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Leucine-rich glioma-inactivated protein 1 antibody-positive limbic encephalitis in a patient with an early-stage asymptomatic breast cancer"],"prefix":"10.1136","volume":"18","author":[{"given":"Maria Fernanda","family":"Ni\u00f1o Uribe","sequence":"first","affiliation":[{"name":"Neurology Department, Centre Hospitalier de Luxembourg, Luxembourg ville, Luxembourg"},{"name":"University of Luxembourg, Esch-sur-Alzette, 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