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There is little evidence on the treatment of such poisoning to guide physicians in caring for these patients. This paper reports on two cases of highly concentrated hydrogen peroxide poisoning after accidental ingestion. Both patients showed evidence of portal venous gas, with one patient exhibiting significant symptoms while the other did not. Both were treated with hyperbaric oxygen therapy (HBOT), with a follow-up CT scan revealing a complete resolution of the portal venous gas. This suggests that HBOT is effective for both symptomatic and asymptomatic patients with portal venous gas and should be considered as an effective treatment option in cases of highly concentrated hydrogen peroxide poisoning.<\/jats:p>","DOI":"10.1136\/bcr-2024-261916","type":"journal-article","created":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T09:45:21Z","timestamp":1739007921000},"page":"e261916","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Two cases of highly concentrated hydrogen peroxide poisoning with portal venous gas treated using hyperbaric oxygen therapy"],"prefix":"10.1136","volume":"18","author":[{"given":"Marie","family":"Vall\u00e9lian","sequence":"first","affiliation":[{"name":"Department of Medicine, General Internal Medicine Service, Geneva University Hospitals, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Juillerat","sequence":"additional","affiliation":[{"name":"Department of Medicine, General Internal Medicine Service, Geneva University Hospitals, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matea","family":"Sunic","sequence":"additional","affiliation":[{"name":"Department of Medicine, General Internal Medicine Service, Inselspital University Hospital Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Medicine, General Internal Medicine Service, Geneva University Hospitals, Geneva, Switzerland"},{"name":"Department of Emergency Medicine & Department of General Internal Medicine, Inselspital University Hospital Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Boet","sequence":"additional","affiliation":[{"name":"Diving and Hyperbaric Unit, Division of Emergency Medicine, Department of Anesthesiology, Pharmacology, Intensive Care and Emergency Medicine, Geneva University Hospitals, Geneve, Switzerland"},{"name":"Department of Anesthesiology and Pain Medicine & Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,2,8]]},"reference":[{"key":"2025082800462564000_18.2.e261916.1","doi-asserted-by":"crossref","unstructured":"Abdollahi M , Hosseini A . 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