{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T05:40:10Z","timestamp":1756359610262,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,1,20]]},"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Behcet\u2019s disease is a chronic, relapsing systemic vasculitis characterised by multisystem involvement from small, medium and large vessel inflammation. Common manifestations include oral and genital ulcers, rash, uveitis and neurological symptoms, while orbital inflammation is rare. An Asian man in his 40s with Behcet\u2019s disease on immunosuppression presented with 10 days of unilateral periorbital swelling and painful eye movements, unresponsive to oral antibiotics. Imaging revealed diffuse orbital inflammation and optic neuritis. Investigations excluded an infectious cause. Despite broad-spectrum intravenous antibiotics, his condition worsened until typical Behcet\u2019s disease mucocutaneous symptoms emerged, indicating a Behcet\u2019s flare. Treatment with high-dose corticosteroids, followed by cyclophosphamide and azathioprine resolved the diffuse orbital inflammation. Unfortunately, the visual outcome was poor as he remained blind in the affected eye from optic neuritis and corneal ulceration. This case highlights the importance of early diagnosis and treatment of diffuse orbital inflammation in Behcet\u2019s disease to prevent severe ocular complications.<\/jats:p>","DOI":"10.1136\/bcr-2024-261942","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T12:06:01Z","timestamp":1738325161000},"page":"e261942","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Diffuse orbital inflammation: an atypical manifestation of Behcet\u2019s disease"],"prefix":"10.1136","volume":"18","author":[{"given":"Evan","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlyn","family":"Shue","sequence":"additional","affiliation":[{"name":"Medical College of Georgia, Augusta University, Augusta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Bell","sequence":"additional","affiliation":[{"name":"Arthritis and Rheumatology Associates of Palm Beach, Inc, West Palm Beach, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Elam","sequence":"additional","affiliation":[{"name":"Department of Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"2025082722192470000_18.1.e261942.1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.autrev.2017.12.006","article-title":"Beh\u00e7et\u2019s disease: New insights into pathophysiology, clinical features and treatment options","volume":"17","author":"Greco","year":"2018","journal-title":"Autoimmun Rev"},{"key":"2025082722192470000_18.1.e261942.2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s12016-021-08864-3","article-title":"A Contemporary Review of Behcet\u2019s Syndrome","volume":"61","author":"Chen","year":"2021","journal-title":"Clin Rev Allergy Immunol"},{"key":"2025082722192470000_18.1.e261942.3","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1093\/rheumatology\/keac531","article-title":"Comparative risk of blindness and vision-threatening ocular comorbidities in patients with Beh\u00e7et\u2019s disease versus the general population","volume":"62","author":"Choi","year":"2023","journal-title":"Rheumatology (Oxford)"},{"key":"2025082722192470000_18.1.e261942.4","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1159\/000095869","article-title":"Acute optic neuropathy in patients with Beh\u00e7et\u2019s disease. 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