{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:09:37Z","timestamp":1790683777799,"version":"4.1.0"},"reference-count":8,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,12,11]]},"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Fibrolamellar hepatocellular carcinoma (FHCC) is a rare variant of hepatocellular carcinoma (HCC), characterised by a poorer prognosis in later stages compared with conventional HCC due to a high rate of local recurrence, lymph node metastasis and peritoneal metastasis. Conventional chemotherapy is generally ineffective, making surgery the only potentially curative treatment. Currently, surgery is also indicated in cases of recurrence, always aiming for an R0 resection.<\/jats:p>\n               <jats:p>We present the case of a young patient with peritoneal and retroperitoneal carcinomatosis following multiple resections, exhibiting a peculiar \u2018sarcomatoid\u2019 pattern of recurrence that is primarily local and not widespread within the abdomen. Immunotherapy was ineffective, and after the third recurrence, a cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy was performed.<\/jats:p>\n               <jats:p>To date, there are no studies on the effectiveness of intraperitoneal chemotherapy in FHCC, though promising results have been observed for conventional HCC. As reported in two other articles in the literature, we attempted to apply this approach to FHCC.<\/jats:p>","DOI":"10.1136\/bcr-2024-261992","type":"journal-article","created":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T22:50:25Z","timestamp":1736031025000},"page":"e261992","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Cytoreductive surgery and HIPEC with oxaliplatin for the treatment of peritoneal carcinomatosis from recurrent fibrolamellar carcinoma"],"prefix":"10.1136","volume":"18","author":[{"given":"Luca","family":"Ballelli","sequence":"first","affiliation":[{"name":"Medicine and surgery, Universit\u00e0 degli Studi di Perugia, Perugia, Umbria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Vicente","sequence":"additional","affiliation":[{"name":"Hospital Universitario HM Sanchinarro, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Quijano","sequence":"additional","affiliation":[{"name":"Hospital Universitario HM Sanchinarro, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Ferri","sequence":"additional","affiliation":[{"name":"General Surgery, Hospital Universitario HM Sanchinarro, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,1,4]]},"reference":[{"key":"2025082702460925000_18.1.e261992.1","doi-asserted-by":"crossref","first-page":"154655","DOI":"10.1016\/j.prp.2023.154655","article-title":"Exploring the molecular pathogenesis, diagnosis and treatment of fibrolamellar hepatocellular carcinoma: A state of art review of the current literature","volume":"248","author":"Alshareefy","year":"2023","journal-title":"Pathol Res Pract"},{"key":"2025082702460925000_18.1.e261992.2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.282075153"},{"key":"2025082702460925000_18.1.e261992.3","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-023-05621-z"},{"key":"2025082702460925000_18.1.e261992.4","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.3390\/biomedicines11092582","article-title":"Advances in Histological and Molecular Classification of Hepatocellular Carcinoma","volume":"11","author":"Choi","year":"2023","journal-title":"Biomedicines"},{"key":"2025082702460925000_18.1.e261992.5","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/j.ejso.2018.05.021","article-title":"Is there an oncological interest in the combination of CRS\/HIPEC for peritoneal carcinomatosis of HCC? Results of a multicenter international study","volume":"44","author":"Mehta","year":"2018","journal-title":"Eur J Surg Oncol"},{"key":"2025082702460925000_18.1.e261992.6","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s12029-019-00236-7","article-title":"Cytoreductive Surgery and HIPEC for Recurrent Fibrolamellar Hepatocellular Carcinoma with Peritoneal Carcinomatosis","volume":"51","author":"Kyziridis","year":"2020","journal-title":"J Gastrointest Canc"},{"key":"2025082702460925000_18.1.e261992.7","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1055\/s-2001-14738","article-title":"Multivisceral resection and intraoperative hyperthermic intraperitoneal chemotherapy in recurrent intra- and extrahepatic fibrolamellar carcinoma of the liver. An individual treatment protocol for a 21-year-old patient","volume":"126","author":"Braune","year":"2001","journal-title":"Zentralbl Chir"},{"key":"2025082702460925000_18.1.e261992.8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jviscsurg.2015.11.010","article-title":"Peritoneal carcinomatosis from unusual cancer origins: Is there a role for hyperthermic intraperitoneal chemotherapy?","volume":"153","author":"Honor\u00e9","year":"2016","journal-title":"J Visc Surg"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-261992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:46:18Z","timestamp":1756287978000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-261992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,4]]},"published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1136\/bcr-2024-261992"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-261992","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]}}}