{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T08:12:14Z","timestamp":1776413534545,"version":"3.51.2"},"reference-count":9,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,5,7]]},"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>A young male patient presented with acute onset spastic quadriparesis. Clinically, he exhibited features of acromegaly alongside spastic quadriparesis. Neuroimaging revealed an osteophyte complex causing cord compression and canal stenosis. Biochemical and radiological assessments confirmed a growth hormone-secreting pituitary macroadenoma. He underwent anterior cervical discectomy with vertebral fusion of the cervical cord to relieve his neurological symptoms. His acromegaly was subsequently managed with surgery, followed by radiotherapy and medical therapy. While acromegaly may rarely present as a metabolic emergency, neurological emergencies are exceptionally rare. This is the first case report of acromegaly, which was recognised on presentation with an osteophyte complex causing quadriparesis.<\/jats:p>","DOI":"10.1136\/bcr-2024-262123","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T05:45:13Z","timestamp":1747806313000},"page":"e262123","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Cervical osteophyte complex causing compressive myelopathy leading to a diagnosis of acromegaly"],"prefix":"10.1136","volume":"18","author":[{"given":"Shilika","family":"Lalwani","sequence":"first","affiliation":[{"name":"Endocrinology, Army Hospital Research and Referral, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8971-0137","authenticated-orcid":false,"given":"Amit","family":"Nachankar","sequence":"additional","affiliation":[{"name":"Endocrinology, Army Hospital Research and Referral, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachin","family":"Modi","sequence":"additional","affiliation":[{"name":"Endocrinology, Army Hospital Research and Referral, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikram Singh","family":"Shekhawat","sequence":"additional","affiliation":[{"name":"Endocrinology, Army Hospital Research and Referral, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"2025082623435748000_18.5.e262123.1","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/839282","article-title":"Osteoarticular changes in acromegaly","volume":"2012","author":"Killinger","year":"2012","journal-title":"Int J Endocrinol"},{"key":"2025082623435748000_18.5.e262123.2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39375"},{"key":"2025082623435748000_18.5.e262123.3","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S2213-8587(22)00244-3","article-title":"Acromegaly: pathogenesis, diagnosis, and management","volume":"10","author":"Fleseriu","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2025082623435748000_18.5.e262123.4","doi-asserted-by":"crossref","DOI":"10.1016\/j.bonr.2022.101628","article-title":"Incidence of ossification of the spinal ligaments in acromegaly patients","volume":"17","author":"Hoshino","year":"2022","journal-title":"Bone Rep"},{"key":"2025082623435748000_18.5.e262123.5","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0022"},{"key":"2025082623435748000_18.5.e262123.6","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0036"},{"key":"2025082623435748000_18.5.e262123.7","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000375450","article-title":"Bone and Joint Disorders in Acromegaly","volume":"103","author":"Claessen","year":"2016","journal-title":"Neuroendocrinology"},{"key":"2025082623435748000_18.5.e262123.8","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.867921","article-title":"Musculoskeletal Effects of Altered GH Action","volume":"13","author":"Young","year":"2022","journal-title":"Front Physiol"},{"key":"2025082623435748000_18.5.e262123.9","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-41887-7","article-title":"Glucose-dependent Insulinotropic Polypeptide (GIP) Resistance and \u03b2-cell Dysfunction Contribute to Hyperglycaemia in Acromegaly","volume":"9","author":"Shekhawat","year":"2019","journal-title":"Sci Rep"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-262123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:44:08Z","timestamp":1756277048000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-262123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":9,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5,21]]},"published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1136\/bcr-2024-262123"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-262123","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]}}}