{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T16:26:08Z","timestamp":1764433568236,"version":"3.44.0"},"reference-count":8,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,10,28]]},"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>We report a case of unilateral serous choroidal effusion in a patient without prior glaucoma surgeries that developed within 1\u2009week of starting topical dorzolamide. A Caucasian female in her 60s with a history of severe primary open-angle glaucoma in the left eye without prior glaucoma surgeries developed irritation and subsequently blurry vision in her left eye within 1\u2009week of starting topical dorzolamide 2% in the left eye only. Funduscopic exam and B-scan ultrasound demonstrated a serous choroidal effusion in the nasal and temporal periphery. After discontinuing dorzolamide and initiating prednisolone and cycloplegic agents, the choroidal effusions fully resolved after 2 weeks, and vision returned to baseline. Choroidal effusion can occur as a result of an idiosyncratic reaction to topical dorzolamide even in patients without prior glaucoma surgeries. Immediate cessation of dorzolamide and treatment with steroid and cycloplegic agents result in good vision recovery for dorzolamide-induced choroidal effusion.<\/jats:p>","DOI":"10.1136\/bcr-2024-262168","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T13:05:24Z","timestamp":1731416724000},"page":"e262168","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Choroidal effusion after initiation of topical dorzolamide treatment"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6515-6557","authenticated-orcid":false,"given":"Derrick James","family":"Wang","sequence":"first","affiliation":[{"name":"Ophthalmology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7012-7216","authenticated-orcid":false,"given":"Peter Feng","family":"Chen","sequence":"additional","affiliation":[{"name":"Ophthalmology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weilin","family":"Chan","sequence":"additional","affiliation":[{"name":"Ophthalmology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria P","family":"Fleming","sequence":"additional","affiliation":[{"name":"Ophthalmology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"2025082804322291000_17.11.e262168.1","unstructured":"Stamper RL , Lieberman MF , Drake MV , et al . Becker-Shaffer\u2019s Diagnosis and Therapy of the Glaucomas. Philadelphia: Mosby\/Elsevier, 2009."},{"key":"2025082804322291000_17.11.e262168.2","first-page":"33","article-title":"Acetazolamide-induced cilio-choroidal effusion after cataract surgery: unusual posterior involvement","volume":"7","author":"Malagola","year":"2013","journal-title":"Drug Des Devel Ther"},{"key":"2025082804322291000_17.11.e262168.3","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/ICU.0000000000000929","article-title":"Risk factors and management of choroidal effusions","volume":"34","author":"Ying","year":"2023","journal-title":"Curr Opin Ophthalmol"},{"key":"2025082804322291000_17.11.e262168.4","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3928\/1542-8877-20031101-07","article-title":"Hypotony and Choroidal Effusion Induced by Topical Timolol and Dorzolamide in Patients With Previous Glaucoma Drainage Device Implantation","volume":"34","author":"Callahan","year":"2003","journal-title":"Ophthalmic Surg Lasers Imaging"},{"key":"2025082804322291000_17.11.e262168.5","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100140239040"},{"key":"2025082804322291000_17.11.e262168.6","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1089\/jop.2006.0050","article-title":"Hypotony and choroidal detachment as a complication of topical combined timolol and dorzolamide","volume":"23","author":"Sharma","year":"2007","journal-title":"J Ocul Pharmacol Ther"},{"key":"2025082804322291000_17.11.e262168.7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ajo.2004.02.070","article-title":"Dorzolamide-induced choroidal detachment in a surgically untreated eye","volume":"138","author":"Goldberg","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"2025082804322291000_17.11.e262168.8","doi-asserted-by":"crossref","first-page":"101866","DOI":"10.1016\/j.ajoc.2023.101866","article-title":"Acute serous and hemorrhagic choroidal effusion associated with topical dorzolamide therapy","volume":"31","author":"Shaheen","year":"2023","journal-title":"Am J Ophthalmol Case Rep"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-262168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:32:27Z","timestamp":1756380747000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-262168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":8,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11,12]]},"published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1136\/bcr-2024-262168"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-262168","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2024,11]]}}}