{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:03:46Z","timestamp":1756339426641,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,11,14]]},"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>A young male in his late 20s presented with brownish discolouration of the conjunctiva and periocular area of both eyes. He was diagnosed as a case of lepromatous leprosy with recurrent type II lepra reaction 4 years ago and was started on multidrug therapy-multi bacillary, which included clofazimine. The best-corrected visual acuity was 20\/20 in both eyes. Examination revealed reddish-brown discolouration of the facial skin including the periorbital area and the eyelids, brownish discolouration of the conjunctiva with shiny sub-conjunctival deposits and multiple polychromatic refractile crystalline corneal deposits. Both eyes had clear lenses with normal fundus. On follow-up after 4 months of discontinuing clofazimine and again after 1 year, the deposits had decreased than previous visits, but they had not totally disappeared. Few studies documented similar ocular side effects of this drug. When diagnosing crystalline deposits in the cornea and conjunctiva, one should rule out clofazimine-induced crystalline keratopathy especially in a leprosy patient.<\/jats:p>","DOI":"10.1136\/bcr-2024-262182","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T10:06:15Z","timestamp":1734516375000},"page":"e262182","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Clofazimine-induced crystalline keratopathy in a leprosy patient"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2577-9383","authenticated-orcid":false,"given":"Richa","family":"Agarwal","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alka","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6814-9050","authenticated-orcid":false,"given":"Shadman","family":"Parveen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kritika","family":"Agnihotri","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"2025082703443595000_17.12.e262182.1","unstructured":"Ramos-e-Silva M , Castro M . Mycobacterial infections. In: Bolognia J , Jorizzo J , Schaffer J , eds. Dermatology, 3rd edn. Elsevier Saunders, 2012: 1221\u20138."},{"key":"2025082703443595000_17.12.e262182.2","first-page":"405","article-title":"Global leprosy update, 2015","volume":"91","year":"2016","journal-title":"Wkly Epidemiol Rec"},{"key":"2025082703443595000_17.12.e262182.3","first-page":"327","article-title":"A review of side-effects experienced by patients taking clofazimine","volume":"54","author":"Moore","year":"1983","journal-title":"Lepr Rev"},{"key":"2025082703443595000_17.12.e262182.4","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-198600610-00003"},{"key":"2025082703443595000_17.12.e262182.5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4103\/1858-5000.157506","article-title":"Hyperpigmentation, a marker of rifampicin overuse in leprosy patient: An incidental finding","volume":"10","author":"Thangaraju","year":"2015","journal-title":"Sudan Med Monit"},{"key":"2025082703443595000_17.12.e262182.6","first-page":"63","article-title":"More about clofazimine--3 years experience and review of literature","volume":"59","author":"Kumar","year":"1987","journal-title":"Indian J Lepr"},{"key":"2025082703443595000_17.12.e262182.7","unstructured":"Gahl WA , Thoene JG , Schneider JA . Cystinosis: a disorder of lysosomal membrane transport scrive. In: Scriver CR , Beaudet AL , Valle D , eds. The metabolic and molecular bases of inherited disease McGraw-Hill. 2001: 5085\u2013108."},{"key":"2025082703443595000_17.12.e262182.8","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.survophthal.2016.11.008","article-title":"Drug-induced corneal epithelial changes","volume":"62","author":"Raizman","year":"2017","journal-title":"Surv Ophthalmol"},{"key":"2025082703443595000_17.12.e262182.9","first-page":"87","article-title":"Effect of clofazimine on eye in multibacillary leprosy","volume":"62","author":"Kaur","year":"1990","journal-title":"Indian J Lepr"},{"key":"2025082703443595000_17.12.e262182.10","doi-asserted-by":"crossref","first-page":"328","DOI":"10.4103\/0301-4738.82012","article-title":"Crystalline deposition in the cornea and conjunctiva secondary to long-term clofazimine therapy in a leprosy patient","volume":"59","author":"Barot","year":"2011","journal-title":"Indian J Ophthalmol"},{"key":"2025082703443595000_17.12.e262182.11","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0161-6420(89)33071-5","article-title":"Polychromatic corneal and conjunctival crystals secondary to clofazimine therapy in a leper","volume":"96","author":"Font","year":"1989","journal-title":"Ophthalmology"},{"key":"2025082703443595000_17.12.e262182.12","doi-asserted-by":"publisher","DOI":"10.1177\/106002809102500513"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-262182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:44:46Z","timestamp":1756291486000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-262182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":12,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12,18]]},"published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1136\/bcr-2024-262182"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-262182","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2024,12]]}}}