{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:45:10Z","timestamp":1793245510971,"version":"4.5.0"},"reference-count":17,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,10,11]]},"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>Adverse drug reactions (ADRs) are common in clinical practice, especially among patients with multiple comorbidities and polypharmacy. The ADRs associated with medications may be minor or life-threatening. Many available ADR assessment scales and pharmacovigilance programmes have streamlined the early diagnosis and management of ADRs. Dobutamine is a commonly used inotropic agent in patients with cardiovascular decompensation which is caused by depressed contractility secondary to organic heart disease, cardiac surgery, cardiac arrest or acute myocardial infarction. Dobutamine-associated adverse effects are mainly due to sympathetic overstimulation causing chest discomfort, palpitations, tremors, headache, shortness of breath, hypertension, nausea, vomiting and eosinophilic myocarditis. Myoclonus is a neurological side effect that may be rarely caused by dobutamine infusion, especially among patients with chronic kidney disease (CKD). We are reporting a rare case of dobutamine-induced multifocal myoclonus in a patient with CKD during the management of decompensated heart failure.<\/jats:p>","DOI":"10.1136\/bcr-2024-262214","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T12:54:45Z","timestamp":1734440085000},"page":"e262214","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Dobutamine induced multifocal myoclonus in a patient with chronic kidney disease"],"prefix":"10.1136","volume":"17","author":[{"given":"Manjappa","family":"Mahadevappa","sequence":"first","affiliation":[{"name":"Department of Cardiology, JSS Medical College and Hosptal, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakeer","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, JSS College of Pharmacy, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasthara","family":"Paneyala","sequence":"additional","affiliation":[{"name":"Department of Neurology, JSS Medical College and Hospital, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U S","family":"Dinesh Kumar","sequence":"additional","affiliation":[{"name":"Department of Cardiac Thoracic and Vascular Anesthesia, JSS Medical college and Hospital, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"2025082709584151000_17.12.e262214.1","unstructured":"Ashkar H , Adnan G , Patel P , et al . Dobutamine. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2024."},{"key":"2025082709584151000_17.12.e262214.2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp060326"},{"key":"2025082709584151000_17.12.e262214.3","doi-asserted-by":"crossref","DOI":"10.1016\/j.xkme.2022.100591","article-title":"Dobutamine-Induced Myoclonus in a Peritoneal Dialysis Patient: Case Report","volume":"5","author":"Noel","year":"2023","journal-title":"Kidney Med"},{"key":"2025082709584151000_17.12.e262214.4","doi-asserted-by":"publisher","DOI":"10.1177\/1756285610395653"},{"key":"2025082709584151000_17.12.e262214.5","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.13005"},{"key":"2025082709584151000_17.12.e262214.6","unstructured":"CKD-EPI creatinine equation. 2021. Available: https:\/\/www.kidney.org\/ckd-epi-creatinine-equation-2021-0"},{"key":"2025082709584151000_17.12.e262214.7","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"2025082709584151000_17.12.e262214.8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1975.03260250028021"},{"key":"2025082709584151000_17.12.e262214.9","unstructured":"Uppsala Monitoring Centre . The use of the WHO\u2013UMC system for standardised case causality assessment. n.d. Available: http:\/\/www.WHO-UMC.org\/graphics\/4409.pdf"},{"key":"2025082709584151000_17.12.e262214.10","first-page":"2229","article-title":"Preventability and severity assessment in reporting adverse drug reactions","volume":"49","author":"Hartwig","year":"1992","journal-title":"Am J Hosp Pharm"},{"key":"2025082709584151000_17.12.e262214.11","first-page":"10118597","article-title":"Focusing on the preventability of adverse drug reactions","volume":"27","author":"Schumock","year":"1992","journal-title":"Hosp Pharm"},{"key":"2025082709584151000_17.12.e262214.12","doi-asserted-by":"crossref","first-page":"S108","DOI":"10.1016\/S1353-8020(13)70027-0","article-title":"Acute and subacute drug-induced movement disorders","volume":"20 Suppl 1","author":"Burkhard","year":"2014","journal-title":"Parkinsonism Relat Disord"},{"key":"2025082709584151000_17.12.e262214.13","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200418020-00003"},{"key":"2025082709584151000_17.12.e262214.14","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh132"},{"key":"2025082709584151000_17.12.e262214.15","doi-asserted-by":"crossref","unstructured":"Zamora M , Shpiner D . Drug-induced Myoclonus in a Patient on Continuous Dobutamine Infusion (5125). Neurol (ECronicon) 2021;96. doi:10.1212\/WNL.96.15_supplement.5125","DOI":"10.1212\/WNL.96.15_supplement.5125"},{"key":"2025082709584151000_17.12.e262214.16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaccas.2024.102255","article-title":"Dobutamine-Induced Myoclonus in a Patient With Advanced Heart Failure and Chronic Kidney Disease","volume":"29","author":"Lee","year":"2024","journal-title":"JACC Case Rep"},{"key":"2025082709584151000_17.12.e262214.17","doi-asserted-by":"crossref","unstructured":"Sunnaa M , Kerolos M , Satterfield M , et al . Dobutamine-Induced Myoclonus: Acute Myoclonus With Continuous Dobutamine and Chronic Kidney Disease. AIM Clinical Cases 2024;3. doi:10.7326\/aimcc.2023.0876","DOI":"10.7326\/aimcc.2023.0876"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-262214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:58:49Z","timestamp":1756313929000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-262214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":17,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12,16]]},"published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1136\/bcr-2024-262214"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-262214","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]}}}