{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:04:14Z","timestamp":1756425854966,"version":"3.44.0"},"reference-count":9,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,3,8]]},"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>Ovarian Sertoli Leydig cell tumours (SLCTs) are rare and occur predominantly in young females. Categorised as less common ovarian cancers, they have a favourable prognosis, and fertility preservation is an option in early-stage disease, where fertility is desired. Here, we describe a case of a late adolescent girl, who presented after tumour excision of left ovarian mass. Her initial histopathology report showed mucinous adenocarcinoma of left ovary. Slide review and immunohistochemistry suggested stage IC, intermediate grade Sertoli Leydig cell tumour and the patient was kept on observation. Six months later, she underwent re-surgery with fertility preservation for suspected recurrence. Final histopathology showed no residual tumour. The girl has been disease-free for 4 years. This case highlights the importance of immunohistochemistry and extensive pathology review for diagnosis of this rare tumour. It emphasises that SLCT can masquerade as other poor-grade malignancies owing to histopathological overlap.<\/jats:p>","DOI":"10.1136\/bcr-2024-262353","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T09:56:09Z","timestamp":1743846969000},"page":"e262353","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Role of immunohistochemistry in the fertility-sparing management of Sertoli Leydig cell tumour"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4147-0645","authenticated-orcid":false,"given":"Ipshita","family":"Sahoo","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology (Gynecologic Oncology), AIIMS Rishikesh, Rishikesh, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3721-6350","authenticated-orcid":false,"given":"Shalini","family":"Rajaram","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology (Gynecologic Oncology), AIIMS Rishikesh, Rishikesh, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7518-5826","authenticated-orcid":false,"given":"Parmita","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology (Gynecologic Oncology), AIIMS Rishikesh, Rishikesh, Uttarakhand, India"},{"name":"Department of Gynecologic Oncology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8430-0216","authenticated-orcid":false,"given":"Prashant","family":"Durgapal","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, AIIMS Rishikesh, Rishikesh, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,4,5]]},"reference":[{"key":"2025082804131255000_18.4.e262353.1","doi-asserted-by":"crossref","unstructured":"Russell P , Robboy SJ , Prat J , et al . Ovarian sex cord stromal and steroid cell tumors. In: Robboy SJ , Mutter GL , Prat J , eds. Robboy\u2019s pathology of the female reproductive tract. 2nd edn. London: Churchill Livingstone, 2009: 708.","DOI":"10.1016\/B978-0-443-07477-6.50031-7"},{"key":"2025082804131255000_18.4.e262353.2","doi-asserted-by":"crossref","first-page":"e360","DOI":"10.1016\/S1470-2045(20)30091-7","article-title":"ESGO-SIOPE guidelines for the management of adolescents and young adults with non-epithelial ovarian cancers","volume":"21","author":"Sessa","year":"2020","journal-title":"Lancet Oncol"},{"key":"2025082804131255000_18.4.e262353.3","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.ygyno.2012.03.024","article-title":"Ovarian Sertoli-Leydig cell tumors. a retrospective MITO study","volume":"125","author":"Sigismondi","year":"2012","journal-title":"Gynecol Oncol"},{"key":"2025082804131255000_18.4.e262353.4","doi-asserted-by":"crossref","first-page":"290","DOI":"10.4103\/0973-1482.158037","article-title":"Ovarian sertoli-leydig cell tumors: A multicenter long-term clinicopathological analysis of 27 patients","volume":"12","author":"Akman","year":"2016","journal-title":"J Cancer Res Ther"},{"key":"2025082804131255000_18.4.e262353.5","doi-asserted-by":"crossref","first-page":"6861","DOI":"10.4081\/rt.2017.6861","article-title":"Sertoli-Leydig cell tumor of the ovary masquerading as a mucinous adenocarcinoma: a frozen section pitfall","volume":"9","author":"Zuckerman","year":"2017","journal-title":"Rare Tumors"},{"key":"2025082804131255000_18.4.e262353.6","unstructured":"Buza N . Sertoli-leydig cell tumor. pathologyoutlines.com. Available: https:\/\/www.pathologyoutlines.com\/topic\/ovarytumorsertolileydig.html [Accessed 8 Jul 2024]."},{"key":"2025082804131255000_18.4.e262353.7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.5468\/ogs.2017.60.1.39","article-title":"A novel clinicopathological analysis of early stage ovarian Sertoli-Leydig cell tumors at a single institution","volume":"60","author":"Nam","year":"2017","journal-title":"Obstet Gynecol Sci"},{"key":"2025082804131255000_18.4.e262353.8","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy001"},{"key":"2025082804131255000_18.4.e262353.9","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ejogrb.2021.06.036","article-title":"Ovarian Sertoli-Leydig cell tumours: A systematic review of relapsed cases","volume":"263","author":"Nef","year":"2021","journal-title":"Eur J Obstet Gynecol Reprod Biol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-262353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:13:19Z","timestamp":1756379599000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-262353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":9,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4,5]]},"published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1136\/bcr-2024-262353"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-262353","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2025,4]]}}}