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This case highlights the diagnostic intricacies of GZL and the challenges in choosing optimal therapies, particularly in refractory\/relapsing cases. It is important to recognise GZL as a distinct entity for accurate diagnosis and personalised treatment. This report contributes to raising awareness and enhancing understanding of this rare lymphoma.<\/jats:p>","DOI":"10.1136\/bcr-2024-262396","type":"journal-article","created":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T20:40:19Z","timestamp":1750624819000},"page":"e262396","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Mediastinal grey-zone lymphoma: diagnostic and therapeutic challenges"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5070-3973","authenticated-orcid":false,"given":"Odete","family":"Duarte","sequence":"first","affiliation":[{"name":"Internal Medicine, Unidade Local de Sa\u00fade de Coimbra, Coimbra, Portugal"},{"name":"Faculty of Medicine, University of Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2344-4267","authenticated-orcid":false,"given":"Helder","family":"Esperto","sequence":"additional","affiliation":[{"name":"Internal Medicine, Unidade Local de Sa\u00fade de Coimbra, Coimbra, Portugal"},{"name":"University of Coimbra Institute for Clinical and Biomedical Research, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Pina","sequence":"additional","affiliation":[{"name":"Pathology, Unidade Local de Sa\u00fade de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00edlia","family":"Gomes","sequence":"additional","affiliation":[{"name":"Hematology, Unidade Local de Sa\u00fade de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,6,22]]},"reference":[{"key":"2025082710213841000_18.6.e262396.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2008.03.005"},{"key":"2025082710213841000_18.6.e262396.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2016.07.012"},{"key":"2025082710213841000_18.6.e262396.3","unstructured":"Swerdlow SH , Campo E , Harris NL , et al , eds. 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