{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:40:17Z","timestamp":1756370417223,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"unspecified","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,1,14]]},"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>Macroamylasaemia (MA) is a biochemical disorder characterised by elevated serum amylase activity, resulting from the circulation of a macromolecular complex of amylase bound to a serum component, often an immunoglobulin. The increased molecular weight of this complex prevents the normal renal excretion of the enzyme. A few cases of adult patients with coeliac disease (CD) and MA have been reported, in which the biochemical disorder resolved after treatment with a gluten-free diet. However, in other cases, this resolution did not occur. Here, we report a case of CD masquerading as recurrent pancreatitis due to the presence of MA.<\/jats:p>","DOI":"10.1136\/bcr-2024-262400","type":"journal-article","created":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T06:10:57Z","timestamp":1739686257000},"page":"e262400","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Coeliac disease masquerading as macroamylasaemia"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3480-7994","authenticated-orcid":false,"given":"Bashayer","family":"Al-Rufayi","sequence":"first","affiliation":[{"name":"Gastroenterology Section, Department of Medicine, Prince Mohammad Bin Abdulaziz Hospital, Ministry of National Guard, Madinah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8056-4181","authenticated-orcid":false,"given":"Abdulmalik M","family":"Alsabban","sequence":"additional","affiliation":[{"name":"Gastroenterology Section, Department of Medicine, Prince Mohammad Bin Abdulaziz Hospital, Ministry of National Guard, Madinah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0525-6662","authenticated-orcid":false,"given":"Abbas A","family":"Zagnoon","sequence":"additional","affiliation":[{"name":"Gastroenterology Section, Department of Medicine, Prince Mohammad Bin Abdulaziz Hospital, Ministry of National Guard, Madinah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,2,16]]},"reference":[{"key":"2025082801174835000_18.2.e262400.1","first-page":"63","article-title":"Diagnosing Macroamylasemia in Unexplained Hyperamylasemia","volume":"71","author":"\u0160imac","year":"2017","journal-title":"Acta Med Croatica"},{"key":"2025082801174835000_18.2.e262400.2","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0889-8553(21)00514-8","article-title":"Where does serum amylase come from and where does it go?","volume":"19","author":"Pieper-Bigelow","year":"1990","journal-title":"Gastroenterol Clin North Am"},{"key":"2025082801174835000_18.2.e262400.3","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3748\/wjg.v9.i6.1377","article-title":"Multiple immune disorders in unrecognized celiac disease: a case report","volume":"9","author":"La Villa","year":"2003","journal-title":"World J Gastroenterol"},{"key":"2025082801174835000_18.2.e262400.4","first-page":"65","article-title":"Macro enzymes: prevalence, composition, detection and clinical relevance","volume":"28","author":"Sturk","year":"1990","journal-title":"J Clin Chem Clin Biochem"},{"key":"2025082801174835000_18.2.e262400.5","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002075"},{"key":"2025082801174835000_18.2.e262400.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302253280803"},{"key":"2025082801174835000_18.2.e262400.7","doi-asserted-by":"publisher","DOI":"10.1159\/000171203"},{"key":"2025082801174835000_18.2.e262400.8","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1007\/BF01540292","article-title":"Macroamylasemia disappearance after gluten withdrawal","volume":"34","author":"Van Gossum","year":"1989","journal-title":"Dig Dis Sci"},{"key":"2025082801174835000_18.2.e262400.9","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/j.1572-0241.2001.03746.x","article-title":"Macroamylasemia in patients with celiac disease","volume":"96","author":"Rabsztyn","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"2025082801174835000_18.2.e262400.10","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3109\/00365519709060036","article-title":"Hyperamylasemia due to macroamylasemia in adult gluten enteropathy","volume":"57","author":"Bonetti","year":"1997","journal-title":"Scand J Clin Lab Invest"},{"key":"2025082801174835000_18.2.e262400.11","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1159\/000132771","article-title":"Macroamylasemia as the first manifestation of celiac disease","volume":"2","author":"Depsames","year":"2008","journal-title":"Case Rep Gastroenterol"},{"key":"2025082801174835000_18.2.e262400.12","first-page":"2233","article-title":"Macrolipasemia and celiac disease","volume":"90","author":"Garcia-Gonzalez","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"2025082801174835000_18.2.e262400.13","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90018-2"},{"key":"2025082801174835000_18.2.e262400.14","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9268-0"},{"key":"2025082801174835000_18.2.e262400.15","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1097\/00042737-199911000-00024","article-title":"Macroamylasaemia--a prognostic marker in a syndrome of malabsorption and complete villous atrophy? An uncommon clinical condition","volume":"11","author":"Viswanath","year":"1999","journal-title":"Eur J Gastroenterol Hepatol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-262400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:17:58Z","timestamp":1756369078000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-262400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2,16]]},"published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1136\/bcr-2024-262400"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-262400","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2025,2]]}}}