{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T13:27:46Z","timestamp":1774531666803,"version":"3.50.1"},"reference-count":13,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,2,2]]},"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>Glanzmann thrombasthenia (GT) is a rare haematological disorder with abnormal platelet surface receptor glycoprotein IIb\/IIIa, resulting in faulty platelet aggregation. Patients with GT may present with spontaneous bleeding after trauma or surgery. As the disease is rare, controlling and preventing bleeding in such patients is challenging. We report two cases of previously diagnosed GT presented with abnormal uterine bleeding. The first case was managed medically with tranexamic acid and hormonal therapy to control menstrual bleeding. In contrast, the second case involved a tubo-ovarian endometrioma presenting with heavy menstrual bleeding (HMB) and dysmenorrhoea, which was treated with laparoscopic adhesiolysis and cyst aspiration. Management of HMB and endometriosis is challenging, especially when using invasive procedures such as laparoscopy. Physicians should be familiar with the characteristics of the disease and all possible treatment options to halt the bleeding to avoid morbidity in patients.<\/jats:p>","DOI":"10.1136\/bcr-2024-262429","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T13:05:46Z","timestamp":1739451946000},"page":"e262429","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Difficult management of abnormal uterine bleeding in Glanzmann thrombasthenia"],"prefix":"10.1136","volume":"18","author":[{"given":"Mita","family":"Mandal","sequence":"first","affiliation":[{"name":"Obstetrics & Gynaecology, All India Institute of Medical Sciences, Kalyani, Kalyani, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9689-9194","authenticated-orcid":false,"given":"Subhankar","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Paediatrics, All India Institute of Medical Sciences, Kalyani, Kalyani, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayanti","family":"Paul","sequence":"additional","affiliation":[{"name":"Obstetrics & Gynaecology, All India Institute of Medical Sciences, Kalyani, Kalyani, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subha Ranjan","family":"Samantaray","sequence":"additional","affiliation":[{"name":"Obstetrics & Gynaecology, All India Institute of Medical Sciences, Kalyani, Kalyani, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"2025082801383529000_18.2.e262429.1","doi-asserted-by":"crossref","DOI":"10.1186\/1750-1172-1-10","article-title":"Glanzmann thrombasthenia","volume":"1","author":"Nurden","year":"2006","journal-title":"Orphanet J Rare Dis"},{"key":"2025082801383529000_18.2.e262429.2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1182\/blood.2021014914","article-title":"Procoagulant platelet sentinels prevent inflammatory bleeding through GPIIBIIIA and GPVI","volume":"140","author":"Kaiser","year":"2022","journal-title":"Blood"},{"key":"2025082801383529000_18.2.e262429.3","doi-asserted-by":"crossref","unstructured":"Fiore M , Nurden AT , Nurden P , et al . 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Eur J Hum Genet 2012;20. doi:10.1038\/ejhg.2012.151","DOI":"10.1038\/ejhg.2012.151"},{"key":"2025082801383529000_18.2.e262429.4","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S71319"},{"key":"2025082801383529000_18.2.e262429.5","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12175702","article-title":"Primary Hemostasis Disorders as a Cause of Heavy Menstrual Bleeding in Women of Reproductive Age","volume":"12","author":"Kontogiannis","year":"2023","journal-title":"J Clin Med"},{"key":"2025082801383529000_18.2.e262429.6","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1080\/13697137.2024.2376189","article-title":"Risk of endometrial malignancy in women treated for breast cancer: the BLUSH prediction model - evidence from a comprehensive multicentric retrospective cohort study","volume":"27","author":"Vitale","year":"2024","journal-title":"Climacteric"},{"key":"2025082801383529000_18.2.e262429.7","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/13697137.2023.2205581","article-title":"Hysteroscopic laser ablation of symptomatic uterine fibroids: insights from a prospective study","volume":"26","author":"Vitale","year":"2023","journal-title":"Climacteric"},{"key":"2025082801383529000_18.2.e262429.8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13023-023-02694-6","article-title":"Monozygotic twin cases of endometriosis with Glanzmann thrombasthenia: a case report and review of literature","volume":"18","author":"Rokhgireh","year":"2023","journal-title":"Orphanet J Rare Dis"},{"key":"2025082801383529000_18.2.e262429.9","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.tmrv.2016.01.001","article-title":"New Insights Into the Treatment of Glanzmann Thrombasthenia","volume":"30","author":"Poon","year":"2016","journal-title":"Transfus Med Rev"},{"key":"2025082801383529000_18.2.e262429.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07189.x"},{"key":"2025082801383529000_18.2.e262429.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06343.x"},{"key":"2025082801383529000_18.2.e262429.12","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s13023-023-02787-2","article-title":"Emergency management of patients with Glanzmann thrombasthenia: consensus recommendations from the French reference center for inherited platelet disorders","volume":"18","author":"Fiore","year":"2023","journal-title":"Orphanet J Rare Dis"},{"key":"2025082801383529000_18.2.e262429.13","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1160\/TH09-04-0225","article-title":"Glanzmann\u2019s thrombasthenia (defective platelet integrin alphaIIb-beta3): proposals for management between evidence and open issues","volume":"102","author":"Di Minno","year":"2009","journal-title":"Thromb Haemost"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-262429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:38:46Z","timestamp":1756370326000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-262429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":13,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2,13]]},"published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1136\/bcr-2024-262429"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-262429","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]}}}