{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:06:36Z","timestamp":1756339596113,"version":"3.44.0"},"reference-count":27,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,5,24]]},"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>Oculomotor nerve palsy in children is rare and results from dysfunction along the course of the nerve, extending from the midbrain to its innervation of the extraocular muscles. While acquired third nerve palsy secondary to a tortuous posterior cerebral artery (PCA) has been reported in adults and older children, it is rarely seen in congenital cases. Congenital third nerve palsy may occur in isolation or be associated with various central nervous system abnormalities. We present a case of right pupil-involving congenital third nerve palsy caused by compression from the PCA. The child, with no other neurological anomalies, presented with drooping of the eyelid and outward deviation of the right eye since birth. Clinical examination revealed complicated ptosis in the right eye with pupil involvement, marked exotropia, an inability to adduct the eye beyond the midline and impaired vertical movements. A contrast-enhanced MRI of the brain showed thinning and hyperintensity of the right third cranial nerve, along with kinking of its course due to compression by the right PCA. Ocular alignment was achieved through medial transposition of the split lateral rectus tendon. The child was prescribed optical correction along with occlusion therapy for amblyopia, and ptosis crutches were added for lid ptosis.<\/jats:p>","DOI":"10.1136\/bcr-2024-262438","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T04:30:23Z","timestamp":1749702623000},"page":"e262438","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Isolated congenital third nerve ophthalmoplegia due to potential neurovascular conflict of the posterior cerebral artery"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7118-2329","authenticated-orcid":false,"given":"Vinita","family":"Gupta","sequence":"first","affiliation":[{"name":"Ophthalmology, AIIMS Rishikesh, Rishikesh, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8393-8206","authenticated-orcid":false,"given":"Vishal","family":"Thakkar","sequence":"additional","affiliation":[{"name":"Ophthalmology, Thakkar Eye Clinic, Ahmedabad, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udit","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Radiology, AIIMS Rishikesh, Rishikesh, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"key":"2025082712161838000_18.6.e262438.1","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2014-205063","article-title":"Oculomotor nerve palsy secondary to aberrant posterior cerebral artery","volume":"2014","author":"Tan","year":"2014","journal-title":"BMJ Case Rep"},{"key":"2025082712161838000_18.6.e262438.2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/eye.1996.77","article-title":"Acquired palsy of the oculomotor, trochlear and abducens nerves","volume":"10","author":"Tiffin","year":"1996","journal-title":"Eye (Lond)"},{"key":"2025082712161838000_18.6.e262438.3","first-page":"104","article-title":"Isolated Internal Ophthalmoplegia from Posterior Cerebral Artery Neurovascular Conflict","volume":"14","author":"Chronopoulos","year":"2023","journal-title":"Case Rep Ophthalmol"},{"key":"2025082712161838000_18.6.e262438.4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/01.APO.0000617940.70112.be","article-title":"Acquired Ocular Motor Palsy: Current Demographic and Etiological Profile","volume":"9","author":"Phuljhele","year":"2020","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"key":"2025082712161838000_18.6.e262438.5","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/0002-9394(77)90197-0","article-title":"Solitary oculomotor nerve palsy in childhood","volume":"83","author":"Miller","year":"1977","journal-title":"Am J Ophthalmol"},{"key":"2025082712161838000_18.6.e262438.6","doi-asserted-by":"publisher","DOI":"10.1227\/01.neu.0000199160.93257.49"},{"key":"2025082712161838000_18.6.e262438.7","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jaapos.2009.01.012","article-title":"Isolated unilateral mydriasis with delayed oculomotor nerve palsy secondary to intracranial arachnoid cyst","volume":"13","author":"Hustler","year":"2009","journal-title":"J AAPOS"},{"key":"2025082712161838000_18.6.e262438.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-4182(05)80062-6"},{"key":"2025082712161838000_18.6.e262438.9","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/eye.2014.292","article-title":"Cranial nerve palsies in childhood","volume":"29","author":"Lyons","year":"2015","journal-title":"Eye (Lond)"},{"key":"2025082712161838000_18.6.e262438.10","doi-asserted-by":"crossref","unstructured":"Winkler KP , Bahl RS . 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