{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:02:55Z","timestamp":1756339375945,"version":"3.44.0"},"reference-count":8,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,11,7]]},"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>Various neurological complications can occur in multiple myeloma. We report a unique paraneoplastic neurological presentation that led to a multiple myeloma diagnosis. A man in his mid-40s experienced a 6-month progressive decline in vision and gait. Examination demonstrated an upper motor neuron pattern, while MRI showed bilateral corticospinal tractopathy and optic neuropathy. Workup led to a diagnosis of multiple myeloma, while other causes (eg, primary central nervous system demyelination, toxic-metabolic, degenerative) were ruled out. Paraneoplastic antibody panels were negative. There was no evidence of leptomeningeal meningitis or compressive lesions. He significantly improved after multiple myeloma treatment. We attribute his unique presentation to a probable paraneoplastic syndrome given the temporal relationships to multiple myeloma diagnosis and treatment. Paraneoplastic neurological syndromes in haematological cancers are often not well-defined, thus requiring both a broad evaluation and awareness of potential connections.<\/jats:p>","DOI":"10.1136\/bcr-2024-262469","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T01:30:20Z","timestamp":1733275820000},"page":"e262469","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Unusual paraneoplastic neurological presentation associated with multiple myeloma"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6646-3679","authenticated-orcid":false,"given":"Anik","family":"Amin","sequence":"first","affiliation":[{"name":"Neurology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique Chiu","family":"Han","sequence":"additional","affiliation":[{"name":"Neurology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumyar","family":"Ardakani","sequence":"additional","affiliation":[{"name":"Neurology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA"},{"name":"Neurology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6531-9595","authenticated-orcid":false,"suffix":"Jr","given":"Larry D","family":"Anderson","sequence":"additional","affiliation":[{"name":"Internal Medicine - Hematology\/Oncology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"key":"2025082700442829000_17.12.e262469.1","doi-asserted-by":"crossref","unstructured":"Bhatia A , Paleologos NA . Chapter 25 - neurological complications of multiple myeloma. In: Neurological complications of systemic cancer and antineoplastic therapy. 2nd edn. 2022: 415\u201331. Available: https:\/\/doi.org\/10.1016\/B978-0-12-821976-8.00021-9","DOI":"10.1016\/B978-0-12-821976-8.00021-9"},{"key":"2025082700442829000_17.12.e262469.2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70442-5"},{"key":"2025082700442829000_17.12.e262469.3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bjhh.2017.09.004","article-title":"Multiple myeloma and central nervous system involvement: experience of a Brazilian center","volume":"40","author":"Dias","year":"2018","journal-title":"Hematol Transfus Cell Ther"},{"key":"2025082700442829000_17.12.e262469.4","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1136\/practneurol-2019-002205","article-title":"Multiple myeloma with multiple neurological presentations","volume":"19","author":"Smith","year":"2019","journal-title":"Pract Neurol"},{"key":"2025082700442829000_17.12.e262469.5","doi-asserted-by":"crossref","first-page":"154689","DOI":"10.1016\/j.prp.2023.154689","article-title":"Multiple myeloma and its rare paraneoplastic manifestations simmering under the surface","volume":"248","author":"Baloch","year":"2023","journal-title":"Pathol Res Pract"},{"key":"2025082700442829000_17.12.e262469.6","article-title":"Uncommon Presentations of Multiple Myeloma","volume":"12","author":"Tathineni","year":"2020","journal-title":"Cureus"},{"key":"2025082700442829000_17.12.e262469.7","article-title":"Multiple Myeloma in a Young Female Presenting with Neurological Symptoms","volume":"2020","author":"Lee","year":"2020","journal-title":"Case Rep Hematol"},{"key":"2025082700442829000_17.12.e262469.8","doi-asserted-by":"crossref","first-page":"E196","DOI":"10.1016\/j.jns.2015.08.680","article-title":"Paraneoplastic CNS lesions secondary to multiple myeloma: a report of 2 cases. Abstract from the World Congress of Neurology 2015","volume":"357","author":"Dhawan","year":"2015","journal-title":"J Neurol Sci"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-262469","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:44:40Z","timestamp":1756280680000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-262469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":8,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12,3]]},"published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1136\/bcr-2024-262469"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-262469","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2024,12]]}}}