{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:43:06Z","timestamp":1787787786581,"version":"build-2784847793"},"reference-count":17,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,12,26]]},"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Tumour-induced osteomalacia (TIO) is an uncommon, debilitating disorder often characterised by non-specific clinical manifestations, posing a significant diagnostic challenge. The tumours causing TIO can be minuscule and occur in unusual areas, further complicating diagnosis. This report details the case of a woman in her early 30s presenting with chronic pain who subsequently developed fragility fractures. The evaluation revealed hypophosphataemia with evidence of renal phosphate wasting demonstrated by a low ratio of tubular maximum reabsorption of phosphate to the glomerular filtration rate for her age. Ga-68 DOTANOC positron emission tomography\/CT successfully localised the fibroblast growth factor-23-secreting tumour at the lower table of the mandible close to the mentum. Given the overall general health condition of the patient, radiofrequency ablation (RFA), a minimally invasive approach, was performed despite surgical resection remaining the traditional gold standard treatment. Following RFA, the patient reported significant symptomatic improvement and regained mobility through rehabilitative measures.<\/jats:p>","DOI":"10.1136\/bcr-2024-262528","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T07:00:42Z","timestamp":1736838042000},"page":"e262528","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Radiofrequency ablation in tumour-induced osteomalacia: a therapeutic challenge"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5923-718X","authenticated-orcid":false,"given":"Sanjana","family":"Jayaraj Mangala","sequence":"first","affiliation":[{"name":"Endocrinology, MS Ramaiah Medical College, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5414-8735","authenticated-orcid":false,"given":"Manjunath","family":"Paidakula 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Radiofrequency Ablation. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2024. 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