{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T05:28:14Z","timestamp":1781760494126,"version":"3.54.5"},"reference-count":17,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,4,18]]},"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>Primary splenic angiosarcoma is an extremely rare and aggressive vascular neoplasm associated with high rates of metastasis. A male patient in his 70s presented with thrombocytopenia. Physical examination and blood tests were non-revealing. A large splenic lesion was found on imaging, and splenectomy confirmed the diagnosis of splenic angiosarcoma. A PET scan and brain MRI showed no evidence of metastasis. The patient is now under surveillance with imaging. Primary splenic angiosarcoma presents a significant clinical challenge due to its aggressive nature and nonspecific symptoms, with outcomes typically poor despite treatment efforts. Chemotherapeutic options lack consensus due to the rarity of the disease. Most patients present with metastases, and treatment primarily involves resection, with adjuvant therapies considered based on risk factors. This case underscores the importance of considering rare malignancies in the differential diagnosis of patients presenting with thrombocytopenia and nonspecific symptoms. Early detection and prompt intervention are fundamental in improving outcomes.<\/jats:p>","DOI":"10.1136\/bcr-2024-262536","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:30:17Z","timestamp":1746750617000},"page":"e262536","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Primary splenic angiosarcoma presenting as thrombocytopenia"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6407-6501","authenticated-orcid":false,"given":"Talar","family":"Telvizian","sequence":"first","affiliation":[{"name":"Hematology and Oncology, Lankenau Medical Center, Wynnewood, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander C","family":"May","sequence":"additional","affiliation":[{"name":"Hematology and Oncology, Lankenau Medical Center, Wynnewood, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Obed","family":"Agyei","sequence":"additional","affiliation":[{"name":"Hematology and Oncology, Lankenau Medical Center, Wynnewood, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Zeger","sequence":"additional","affiliation":[{"name":"Hematology and Oncology, Lankenau Medical Center, Wynnewood, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"2025082708035646000_18.5.e262536.1","doi-asserted-by":"crossref","unstructured":"Kachramanoglou C , Ibrahim D , Sharma R , et al . Splenic hamartoma. Reference article, radiopaedia.org. Available: https:\/\/doi.org\/10.53347\/rID-19383 [Accessed 30 Mar 2025].","DOI":"10.53347\/rID-19383"},{"key":"2025082708035646000_18.5.e262536.2","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1055\/a-2193-2292","article-title":"Diagnostic approach to splenic lesions","volume":"196","author":"Kr\u00e4hling","year":"2024","journal-title":"Rofo"},{"key":"2025082708035646000_18.5.e262536.3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2214\/AJR.13.11777","article-title":"Nonneoplastic, benign, and malignant splenic diseases: cross-sectional imaging findings and rare disease entities","volume":"203","author":"Thipphavong","year":"2014","journal-title":"AJR Am J Roentgenol"},{"key":"2025082708035646000_18.5.e262536.4","doi-asserted-by":"publisher","DOI":"10.1148\/rg.210071"},{"key":"2025082708035646000_18.5.e262536.5","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.6235","article-title":"Incidence and Presenting Characteristics of Angiosarcoma in the US, 2001-2020","volume":"7","author":"Wagner","year":"2024","journal-title":"JAMA Netw Open"},{"key":"2025082708035646000_18.5.e262536.6","doi-asserted-by":"publisher","DOI":"10.14740\/wjon1542"},{"key":"2025082708035646000_18.5.e262536.7","first-page":"193036","article-title":"Primary angiosarcoma of the spleen: an oncological enigma","volume":"2014","author":"Myoteri","year":"2014","journal-title":"Case Rep Oncol Med"},{"key":"2025082708035646000_18.5.e262536.8","doi-asserted-by":"crossref","DOI":"10.4322\/acr.2019.100","article-title":"Primary splenic angiosarcoma: a rare entity often associated with rupture and hemoperitoneum","volume":"9","author":"Fiorentino","year":"2019","journal-title":"Autops Case Rep"},{"key":"2025082708035646000_18.5.e262536.9","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880178"},{"key":"2025082708035646000_18.5.e262536.10","first-page":"14040","article-title":"Primary splenic angiosarcoma with fever and anemia: a case report and literature review","volume":"8","author":"Deng","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"2025082708035646000_18.5.e262536.11","doi-asserted-by":"crossref","first-page":"431","DOI":"10.4293\/108680810X12924466006521","article-title":"Primary splenic angiosarcoma","volume":"14","author":"Hamid","year":"2010","journal-title":"JSLS"},{"key":"2025082708035646000_18.5.e262536.12","doi-asserted-by":"crossref","first-page":"85","DOI":"10.59566\/IJBS.2009.5085","article-title":"Primary tumors of the spleen","volume":"5","author":"Fotiadis","year":"2009","journal-title":"Int J Biomed Sci"},{"key":"2025082708035646000_18.5.e262536.13","doi-asserted-by":"publisher","DOI":"10.2340\/1651-226X.2023.35412"},{"key":"2025082708035646000_18.5.e262536.14","doi-asserted-by":"publisher","DOI":"10.1053\/j.sult.2006.06.004"},{"key":"2025082708035646000_18.5.e262536.15","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1080\/17474124.2021.1945920","article-title":"Spleen angiosarcoma: a world review","volume":"15","author":"Juin Hsien","year":"2021","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"2025082708035646000_18.5.e262536.16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijscr.2021.105929","article-title":"Primary angiosarcoma of the spleen, a rare indication for splenectomy: a case report","volume":"82","author":"Wheelwright","year":"2021","journal-title":"Int J Surg Case Rep"},{"key":"2025082708035646000_18.5.e262536.17","first-page":"369","article-title":"Primary hemangiosarcoma of the spleen associated with leukocytosis and abnormal spleen scan","volume":"65","author":"Montemayor","year":"1980","journal-title":"Int Surg"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-262536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:04:04Z","timestamp":1756307044000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-262536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":17,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5,8]]},"published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1136\/bcr-2024-262536"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-262536","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]}}}