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Laboratory results confirmed the diagnosis of SLE with low disease activity. Anti-RNP antibodies were positive alongside other common markers of SLE, which pointed towards a rare entity called lupus psychosis. She was started on immunosuppression with methylprednisolone and cyclophosphamide combined with antipsychotics. Following treatment, she improved significantly and is currently leading a normal life.<\/jats:p>","DOI":"10.1136\/bcr-2024-262637","type":"journal-article","created":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T20:50:39Z","timestamp":1737319839000},"page":"e262637","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Lupus psychosis: an unusual cause of acute confusion presenting to acute medicine"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6122-8776","authenticated-orcid":false,"given":"Abhimanyu","family":"Samadder","sequence":"first","affiliation":[{"name":"Acute Medicine, Epsom and Saint Helier Hospital NHS Trust, Carshalton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe","family":"Wang","sequence":"additional","affiliation":[{"name":"Acute Medicine, Epsom and Saint Helier Hospital NHS Trust, Carshalton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritu","family":"Malaiya","sequence":"additional","affiliation":[{"name":"Rheumatology, Epsom and Saint Helier Hospital NHS Trust, Carshalton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,1,19]]},"reference":[{"key":"2025082722223576000_18.1.e262637.1","first-page":"i7","article-title":"Assessing confused patients","volume":"71 Suppl 1","author":"Johnson","year":"2001","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2025082722223576000_18.1.e262637.2","doi-asserted-by":"crossref","first-page":"5620","DOI":"10.1093\/rheumatology\/keab160","article-title":"Psychosis in systemic lupus erythematosus (SLE): 40-year experience of a specialist centre","volume":"60","author":"Abrol","year":"2021","journal-title":"Rheumatol (Oxford)"},{"key":"2025082722223576000_18.1.e262637.3","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0269-8"},{"key":"2025082722223576000_18.1.e262637.4","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.4103\/jfmpc.jfmpc_1475_20","article-title":"Acute psychosis as the presenting manifestation of lupus","volume":"10","author":"Kumar","year":"2021","journal-title":"J Family Med Prim Care"},{"key":"2025082722223576000_18.1.e262637.5","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2019.01142","article-title":"Coexistence of Autoimmune Encephalitis and Other Systemic Autoimmune Diseases","volume":"10","author":"Zhao","year":"2019","journal-title":"Front Neurol"},{"key":"2025082722223576000_18.1.e262637.6","doi-asserted-by":"crossref","first-page":"502","DOI":"10.3988\/jcn.2016.12.4.502","article-title":"Anti-N-Methyl-D-Aspartate Receptor Encephalitis in a Patient with Systemic Lupus Erythematosus","volume":"12","author":"Wu","year":"2016","journal-title":"J Clin Neurol"},{"key":"2025082722223576000_18.1.e262637.7","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/nm1101-1189","article-title":"A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus","volume":"7","author":"DeGiorgio","year":"2001","journal-title":"N Med"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-262637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T05:22:44Z","timestamp":1756358564000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-262637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":7,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,19]]},"published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1136\/bcr-2024-262637"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-262637","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]}}}