{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T11:10:05Z","timestamp":1756293005942,"version":"3.44.0"},"reference-count":8,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,10,22]]},"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>Tuberculosis is a global disease and presents with an array of neurological manifestations. Presentation varies from meningitis, radiculo-myelitis, tuberculoma, brain abscess and other combinations. The association of Guillain-Barre\u2019 syndrome (GBS) with tuberculosis has been reported in a few reports. Neurological tuberculosis association with GBS is very rare. We here report an early adolescent patient with tubercular meningitis and tuberculoma who presented with acute areflexic quadriparesis and was subsequently diagnosed as an acute motor sensory axonal neuropathy variant of GBS. The diagnosis was confirmed with clinical examination, nerve conduction studies, positive anti-ganglioside antibody and clinical response to intravenous immunoglobulin. We present a case of an association between tubercular meningitis clinically presenting as encephalopathy and acute flaccid weakness due to GBS.<\/jats:p>","DOI":"10.1136\/bcr-2024-262702","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T02:20:16Z","timestamp":1731032416000},"page":"e262702","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Complicated neurological pathways: tuberculoma with Guillain-Barre syndrome \u2013 an uncharted clinical odyssey"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5059-0376","authenticated-orcid":false,"given":"Shubham","family":"Verma","sequence":"first","affiliation":[{"name":"Pediatrics, AIIMS Raipur, Raipur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddannagoud","family":"Salotagi","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences, Jodhpur, Jodhpur, Rajasthan, India"},{"name":"Pediatrics, AIIMS Raipur, Raipur, Chhattisgardh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varun M","family":"Angadi","sequence":"additional","affiliation":[{"name":"Pediatrics, AIIMS Raipur, Raipur, Chhattisgardh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manas Ranjan","family":"Sahoo","sequence":"additional","affiliation":[{"name":"Pediatrics, AIIMS Raipur, Raipur, Chhattisgardh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"2025082703523551000_17.11.e262702.1","doi-asserted-by":"crossref","unstructured":"Khan SA , Das PR , Nahar Z , et al . An updated review on Guillain-Barr\u00e9 syndrome: Challenges in infection prevention and control in low- and middle-income countries. SAGE Open Med 2024;12. doi:10.1177\/20503121241239538","DOI":"10.1177\/20503121241239538"},{"key":"2025082703523551000_17.11.e262702.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00339-1"},{"key":"2025082703523551000_17.11.e262702.3","doi-asserted-by":"crossref","unstructured":"Taha AAM , Tee KHA . Guillain-Barr\u00e9 syndrome associated with pulmonary tuberculosis. BMJ Case Rep 2012;2012. doi:10.1136\/bcr-01-2012-5484","DOI":"10.1136\/bcr-01-2012-5484"},{"key":"2025082703523551000_17.11.e262702.4","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1055\/s-0039-1697567","article-title":"Tubercular Meningitis with Acute Inflammatory Demyelinating Polyneuropathy-Trigger or Chance","volume":"10","author":"Dalai","year":"2019","journal-title":"J Neurosci Rural Pract"},{"key":"2025082703523551000_17.11.e262702.5","doi-asserted-by":"crossref","unstructured":"Fernandez-Fu \u0301 nez A , Gomez Garrido J , Alamillo A , et al . Demyelinating polyneuropathy as the Honest form of lymph node tuberculosis. Paradox response in an immunocompetent patient. Med Clin 2007;129. doi:10.1157\/13106942","DOI":"10.1157\/13106942"},{"key":"2025082703523551000_17.11.e262702.6","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.4.5936.107-a","article-title":"Letter: Tuberculous polyradiculitis","volume":"4","author":"Peiris","year":"1974","journal-title":"Br Med J"},{"key":"2025082703523551000_17.11.e262702.7","unstructured":"Sejvar JJ , Kohl KS , Gidudu J , et al . n.d. Brighton Collaboration GBS Working Group. Guillain-Barre syndrome and Fisher."},{"key":"2025082703523551000_17.11.e262702.8","first-page":"139","article-title":"Tuberculous meningitis: An unlikely cause of Guillain-Barre syndrome","volume":"67","author":"Nishanth","year":"2020","journal-title":"Ind J Tuberc"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-262702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:52:43Z","timestamp":1756291963000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-262702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":8,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11,7]]},"published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1136\/bcr-2024-262702"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-262702","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2024,11]]}}}