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Eplerenone was used as a short-term treatment without adverse effects to the fetus before unilateral laparoscopic adrenalectomy was performed in the second trimester after the patient was refractory to medical treatment. This case report adds to the limited literature on management of PA in pregnancy, which could influence future risk-benefit discussions regarding surgical versus medical management of this condition.<\/jats:p>","DOI":"10.1136\/bcr-2024-262767","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:45:22Z","timestamp":1738802722000},"page":"e262767","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Severe hypokalaemia in primary aldosteronism during pregnancy"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0393-6379","authenticated-orcid":false,"given":"Allison","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Endocrine Surgery, Columbia University Irving Medical Center, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7161-3451","authenticated-orcid":false,"given":"Stephanie J","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, Columbia University Irving Medical Center, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P","family":"Crapanzano","sequence":"additional","affiliation":[{"name":"Department of Pathology & Cell Biology, Columbia University Irving Medical Center, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, Columbia University Irving Medical Center, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"2025082802172495000_18.2.e262767.1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41574-022-00730-2","article-title":"Primary aldosteronism - 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