{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:10:07Z","timestamp":1756307407404,"version":"3.44.0"},"reference-count":19,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,4,8]]},"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>Posterior mediastinal masses frequently originate from neurogenic tumours; however, other possible causes include vascular abnormalities, cysts and primary bone tumours. We present a case involving a man in his 20s who experienced back pain, sudden sensorimotor weakness in both lower limbs and loss of bladder control. Imaging studies, including CT and MRI, identified a posterior mediastinal extramedullary mass associated with vertebral destruction and intrathecal extension. A biopsy of the mass confirmed it to be a giant cell tumour of bone. The patient was treated with denosumab, steroids and spinal decompression and was scheduled for definitive surgery. In young individuals presenting with a posterior mediastinal mass, signs of inflammation and early neurological symptoms, it is essential to consider primary bone tumours as a possible diagnosis.<\/jats:p>","DOI":"10.1136\/bcr-2024-262838","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T09:25:33Z","timestamp":1747387533000},"page":"e262838","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Spinal giant cell tumour presenting as a posterior mediastinal mass"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7325-2001","authenticated-orcid":false,"given":"Balaji K","family":"Vijay","sequence":"first","affiliation":[{"name":"Pulmonary Critical Care and Sleep Medicine, All India Institute of Medical Sciences Jodhpur, Jodhpur, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Durgeshwar","family":"Gopal","sequence":"additional","affiliation":[{"name":"Pulmonary Critical Care and Sleep Medicine, All India Institute of Medical Sciences Jodhpur, Jodhpur, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garg","family":"Pawan Kumar","sequence":"additional","affiliation":[{"name":"Radiology, All India Institute of Medical Sciences Jodphur, Jodhpur, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meenakshi","family":"Rao","sequence":"additional","affiliation":[{"name":"Pulmonary Critical Care and Sleep Medicine, All India Institute of Medical Sciences Jodhpur, Jodhpur, Rajasthan, India"},{"name":"Department of Pathology & Lab Medicine, All India Institute of Medical sciences, Jodhpur, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"doi-asserted-by":"publisher","key":"2025082707553314000_18.5.e262838.1","DOI":"10.1002\/1097-0142(197005)25:5<1061::AID-CNCR2820250509>3.0.CO;2-E"},{"doi-asserted-by":"publisher","key":"2025082707553314000_18.5.e262838.2","DOI":"10.1148\/rg.331125089"},{"doi-asserted-by":"publisher","key":"2025082707553314000_18.5.e262838.3","DOI":"10.1097\/00003086-200204000-00029"},{"doi-asserted-by":"publisher","key":"2025082707553314000_18.5.e262838.4","DOI":"10.1148\/radiographics.21.5.g01se251283"},{"doi-asserted-by":"publisher","key":"2025082707553314000_18.5.e262838.5","DOI":"10.1097\/01.coc.0000195089.11620.b7"},{"key":"2025082707553314000_18.5.e262838.6","doi-asserted-by":"crossref","first-page":"e296","DOI":"10.1016\/j.wneu.2020.08.135","article-title":"Incidence, Management, and Outcomes of Spinal Giant Cell Tumor of Bone in Adult Patients: A National Cancer Database Analysis","volume":"144","author":"Patel","year":"2020","journal-title":"World Neurosurg"},{"key":"2025082707553314000_18.5.e262838.7","doi-asserted-by":"crossref","DOI":"10.1007\/s11912-021-01047-5","article-title":"Giant Cell Tumor of Bone: An Update","volume":"23","author":"Basu Mallick","year":"2021","journal-title":"Curr Oncol Rep"},{"doi-asserted-by":"publisher","key":"2025082707553314000_18.5.e262838.8","DOI":"10.1002\/mpo.10258"},{"unstructured":"Siegal G , Bloem JL , Cates JMM . 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