{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T13:37:16Z","timestamp":1776865036899,"version":"3.51.2"},"reference-count":23,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,2,10]]},"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>Epstein-Barr virus (EBV) affects over 90% of the global population and has been linked to several autoimmune disorders. This report describes a patient with EBV-associated hepatitis who subsequently developed aplastic anaemia, pernicious anaemia and autoimmune thyroiditis. The patient was treated with an immunosuppressive regimen with gradual improvement in his pancytopenia and autoimmune thyroiditis. This report highlights the importance of a comprehensive evaluation and close monitoring of patients presenting with acute or recent EBV infection. Clinicians are urged to recognise autoimmune sequelae, as early intervention can be life-saving.<\/jats:p>","DOI":"10.1136\/bcr-2024-262950","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T23:55:18Z","timestamp":1740441318000},"page":"e262950","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Aplastic anaemia, pernicious anaemia and autoimmune thyroiditis following an episode of EBV-associated hepatitis"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8876-5192","authenticated-orcid":false,"given":"Melissa","family":"Gunchenko","sequence":"first","affiliation":[{"name":"Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandler","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivi","family":"Jain","sequence":"additional","affiliation":[{"name":"Internal Medicine, Hematology\/Oncology, Rush University Medical Center, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamideh","family":"Doozandeh","sequence":"additional","affiliation":[{"name":"Pathology, Rush University Medical Center, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"2025082710504306000_18.2.e262950.1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-014-8496-1"},{"key":"2025082710504306000_18.2.e262950.2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-023-00775-5"},{"key":"2025082710504306000_18.2.e262950.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2008.09.007"},{"key":"2025082710504306000_18.2.e262950.4","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.587380","article-title":"Epstein-Barr Virus and Systemic Autoimmune Diseases","volume":"11","author":"Houen","year":"2020","journal-title":"Front Immunol"},{"key":"2025082710504306000_18.2.e262950.5","unstructured":"Epstein-Barr virus. StatPearls - NCBI Bookshelf, 2024. Available: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK559285\/"},{"key":"2025082710504306000_18.2.e262950.6","unstructured":"Epstein-Barr virus and autoimmune diseases. National Institutes of Health (NIH), 2024. Available: https:\/\/www.nih.gov\/news-events\/nih-research-matters\/epstein-barr-virus-autoimmune-diseases"},{"key":"2025082710504306000_18.2.e262950.7","first-page":"132","article-title":"Multiple autoimmune syndrome","volume":"5","author":"Cojocaru","year":"2010","journal-title":"Maedica (Bucur)"},{"key":"2025082710504306000_18.2.e262950.8","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-008-0671-9"},{"key":"2025082710504306000_18.2.e262950.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704103361504"},{"key":"2025082710504306000_18.2.e262950.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08194.x"},{"key":"2025082710504306000_18.2.e262950.11","unstructured":"Elkomos-Botros G . n.d. A case of new onset autoimmune thyroid disease following acute Epstein Barr virus (EBV) infection. J Hosp Med."},{"key":"2025082710504306000_18.2.e262950.12","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.2169\/internalmedicine.49.3978","article-title":"Graves\u2019 Disease Associated with Infectious Mononucleosis due to Primary Epstein-Barr Virus Infection: Report of 3 Cases","volume":"49","author":"Akahori","year":"2010","journal-title":"Intern Med"},{"key":"2025082710504306000_18.2.e262950.13","doi-asserted-by":"crossref","DOI":"10.1177\/17562848211038771","article-title":"Autoimmune gastritis, with or without pernicious anemia: epidemiology, risk factors, and clinical management","volume":"14","author":"Rustgi","year":"2021","journal-title":"Therap Adv Gastroenterol"},{"key":"2025082710504306000_18.2.e262950.14","unstructured":"Vaqar S , Shackelford KB . Pernicious anemia. In: StatPearls. 2023. Available: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK540989\/"},{"key":"2025082710504306000_18.2.e262950.15","doi-asserted-by":"crossref","first-page":"924","DOI":"10.7150\/ijms.71820","article-title":"Epstein-Barr Virus is Associated with Gastric Cancer Precursor: Atrophic Gastritis","volume":"19","author":"Zhao","year":"2022","journal-title":"Int J Med Sci"},{"key":"2025082710504306000_18.2.e262950.16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.5501\/wjv.v1.i1.31","article-title":"Serological diagnosis of Epstein-Barr virus infection: Problems and solutions","volume":"1","author":"De Paschale","year":"2012","journal-title":"World J Virol"},{"key":"2025082710504306000_18.2.e262950.17","unstructured":"Laboratory testing for Epstein-Barr virus (EBV) | Epstein-Barr virus and infectious mononucleosis | CDC. 2024. Available: https:\/\/www.cdc.gov\/epstein-barr\/php\/laboratories\/index.html"},{"key":"2025082710504306000_18.2.e262950.18","first-page":"357","article-title":"Maladie de biermer r\u00e9v\u00e9l\u00e9e par une h\u00e9patite \u00e0 Epstein-Barr virus","volume":"12","author":"Ndiaye","year":"2006","journal-title":"Hematologie"},{"key":"2025082710504306000_18.2.e262950.19","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24051-6"},{"key":"2025082710504306000_18.2.e262950.20","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0102-3"},{"key":"2025082710504306000_18.2.e262950.21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa2109965","article-title":"Eltrombopag Added to Immunosuppression in Severe Aplastic Anemia","volume":"386","author":"Peffault de Latour","year":"2022","journal-title":"N Engl J Med"},{"key":"2025082710504306000_18.2.e262950.22","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1056\/NEJMoa1613878","article-title":"Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia","volume":"376","author":"Townsley","year":"2017","journal-title":"N Engl J Med"},{"key":"2025082710504306000_18.2.e262950.23","doi-asserted-by":"crossref","first-page":"16899","DOI":"10.1038\/s41598-019-53475-w","article-title":"An Evaluation of the Results of the Steroid and Non-steroidal Anti-inflammatory Drug Treatments in Subacute Thyroiditis in relation to Persistent Hypothyroidism and Recurrence","volume":"9","author":"Sencar","year":"2019","journal-title":"Sci Rep"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-262950","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:50:48Z","timestamp":1756317048000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-262950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2,24]]},"published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1136\/bcr-2024-262950"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-262950","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]}}}