{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:10:14Z","timestamp":1756379414898,"version":"3.44.0"},"reference-count":6,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,3,2]]},"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:p>Tuberous xanthomas, a variety of the broad category of xanthomas, are a result of abnormalities in the lipoprotein metabolism, often familial in nature. These nodular swellings typically arise over the extensor aspect of the body, such as the elbows and the knees. A worrisome entity associated with them is the uncontrolled hyperlipidaemia, especially in young individuals. Here, we present two young brothers with such rare clinical signs and other manifestations of hyperlipidaemia, highlighting that thorough head-to-toe examination with the right set of investigations can aid in the diagnosis and management.<\/jats:p>","DOI":"10.1136\/bcr-2024-262973","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T16:26:36Z","timestamp":1742401596000},"page":"e262973","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Two siblings with tuberous xanthomas: case report"],"prefix":"10.1136","volume":"18","author":[{"given":"Tejaswini","family":"Girish","sequence":"first","affiliation":[{"name":"Department of General Surgery, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Karnataka, Manipal, 576104, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kawari Sowbhagyalaxmi","family":"Ramesh","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Karnataka, Manipal, 576104, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil Kumar","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Karnataka, Manipal, 576104, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sneha","family":"Rao A R","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Karnataka, Manipal, 576104, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"2025082803524508000_18.3.e262973.1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.4103\/0974-2077.101384","article-title":"Giant Tuberous Xanthomas in a Case of Type IIA Hypercholesterolemia","volume":"5","author":"Babu","year":"2012","journal-title":"J Cutan Aesthet Surg"},{"key":"2025082803524508000_18.3.e262973.2","doi-asserted-by":"crossref","unstructured":"Bommakanti S , Logeshwari J . A Case Report of Giant Tuberous Xanthoma with Type IIa Familial Hypercholesterolemia. Indian Journal of Paediatric Dermatology 2024. doi:10.4103\/ijpd.ijpd_36_23","DOI":"10.4103\/ijpd.ijpd_36_23"},{"key":"2025082803524508000_18.3.e262973.3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4103\/2229-5178.202265","article-title":"Extensive Giant Tuberous Xanthomas in a 12-Year-Old Boy","volume":"8","author":"Vora","year":"2017","journal-title":"Indian Dermatol Online J"},{"key":"2025082803524508000_18.3.e262973.4","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5406-7"},{"key":"2025082803524508000_18.3.e262973.5","doi-asserted-by":"crossref","first-page":"106596","DOI":"10.1016\/j.ijscr.2021.106596","article-title":"Surgical treatment of multiple large tuberous xanthomas in familial hypercholesterolemia: A case report","volume":"89","author":"Dung","year":"2021","journal-title":"Int J Surg Case Rep"},{"key":"2025082803524508000_18.3.e262973.6","doi-asserted-by":"crossref","first-page":"961","DOI":"10.2147\/CCID.S445163","article-title":"Surgical Treatment of Multiple Large Tuberous and Tendinous Xanthoma Secondary to Familial Hypercholesterolaemia: A Case Report","volume":"17","author":"Guan","year":"2024","journal-title":"Clin Cosmet Investig Dermatol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-262973","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:52:56Z","timestamp":1756378376000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-262973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":6,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,3,19]]},"published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1136\/bcr-2024-262973"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-262973","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2025,3]]}}}