{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:45:02Z","timestamp":1782891902439,"version":"3.54.5"},"reference-count":20,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,2,10]]},"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>Extranodal involvement in lymphomas is well-documented in the literature. However, certain anatomical sites, such as the epidural space, are rarely affected by lymphoproliferative neoplasms. When lymphomas are confined to the epidural space without other recognisable sites of involvement at diagnosis, they are classified as primary spinal epidural lymphoma. We report the case of a man in his early 30s who presented with lower back pain and progressive quadriparesis. Imaging revealed an extradural mass extending from the sixth to the tenth thoracic vertebrae, with lateral extension into the extrapleural space. A biopsy confirmed diffuse large B-cell lymphoma, and the patient was started on combination chemotherapy.<\/jats:p>","DOI":"10.1136\/bcr-2024-263069","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T20:35:20Z","timestamp":1739997320000},"page":"e263069","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Epidural lymphoma: a rare presentation of extranodal disease"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7068-9806","authenticated-orcid":false,"given":"Vijay","family":"Alexander","sequence":"first","affiliation":[{"name":"Department of Hepatology, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon Anbumalar","family":"Lionel","sequence":"additional","affiliation":[{"name":"Department of Haematology, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6602-4369","authenticated-orcid":false,"given":"George Abraham","family":"Ninan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"George","sequence":"additional","affiliation":[{"name":"Department of Medicine, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"2025082709233375000_18.2.e263069.1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/0974-8237.85307","article-title":"Primary spinal epidural lymphomas","volume":"2","author":"Cugati","year":"2011","journal-title":"J Craniovert Jun Spine"},{"key":"2025082709233375000_18.2.e263069.2","doi-asserted-by":"crossref","first-page":"565","DOI":"10.5858\/2008-132-565-EL","article-title":"Extranodal lymphoma","volume":"132","author":"Ferry","year":"2008","journal-title":"Arch Pathol Lab Med"},{"key":"2025082709233375000_18.2.e263069.3","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1177\/10935266211033269","article-title":"Hodgkin Lymphoma Presenting With Spinal Cord Compression: Challenges for Diagnosis and Initial Management","volume":"25","author":"Bloxham","year":"2022","journal-title":"Pediatr Dev Pathol"},{"key":"2025082709233375000_18.2.e263069.4","doi-asserted-by":"crossref","DOI":"10.1002\/ccr3.9319","article-title":"Lumbosacral epidural lymphoma: A case report and comprehensive review of literature","volume":"12","author":"Eslami","year":"2024","journal-title":"Clin Case Rep"},{"key":"2025082709233375000_18.2.e263069.5","first-page":"907","article-title":"Malignant lymphoma in the central nervous system: overview","volume":"66","author":"Namekawa","year":"2014","journal-title":"Brain Nerve"},{"key":"2025082709233375000_18.2.e263069.6","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.ijrobp.2006.01.002","article-title":"Primary spinal epidural lymphoma: patients\u2019 profile, outcome, and prognostic factors: a multicenter Rare Cancer Network study","volume":"65","author":"Monnard","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2025082709233375000_18.2.e263069.7","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-017-3093-z","article-title":"Clinicopathologic characteristics and prognostic factors for primary spinal epidural lymphoma: report on 36 Chinese patients and review of the literature","volume":"17","author":"Xiong","year":"2017","journal-title":"BMC Cancer"},{"key":"2025082709233375000_18.2.e263069.8","first-page":"1228","article-title":"Malignant lymphomas of the spinal epidural space","volume":"24","author":"Dj","year":"1944","journal-title":"Surg Clin North Am"},{"key":"2025082709233375000_18.2.e263069.9","doi-asserted-by":"crossref","first-page":"66","DOI":"10.14791\/btrt.2022.0038","article-title":"A Rare Occurrence of Primarily Extranodal Spinal Epidural Lymphoma With Spinal Cord Compression and Invasion to the Thoracic Cavity","volume":"11","author":"Seok","year":"2023","journal-title":"Brain Tumor Res Treat"},{"key":"2025082709233375000_18.2.e263069.10","doi-asserted-by":"publisher","DOI":"10.1177\/028418519203300410"},{"key":"2025082709233375000_18.2.e263069.11","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s43055-021-00597-9","article-title":"Role of diffusion MRI in diagnosis of mediastinal lymphoma: initial assessment and response to therapy","volume":"52","author":"Sabri","year":"2021","journal-title":"Egypt J Radiol Nucl Med"},{"key":"2025082709233375000_18.2.e263069.12","doi-asserted-by":"crossref","unstructured":"Yasin . 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