{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:52:12Z","timestamp":1793163132645,"version":"4.5.0"},"reference-count":13,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,5,1]]},"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>Thyroid metastasis (TM) from oropharyngeal squamous cell carcinoma (OPSCC) is exceedingly rare, with limited cases reported. Despite the vascular nature of the thyroid gland, its microenvironment does not favour metastatic spread.<\/jats:p>\n                  <jats:p>This case describes a male in his late 70s with p16-positive tonsillar SCC who presented with diffuse TM. The patient initially presented with dysphonia and weight loss, leading to a diagnosis of advanced SCC centred in the right tonsil with bilateral cervical lymphadenopathy. Further work-up revealed extensive thyroid involvement, confirmed by fine needle aspiration showing p16-positive SCC.<\/jats:p>\n                  <jats:p>This report highlights the need to consider uncommon sites of metastasis in patients with advanced OPSCC, especially those with human papillomavirus as a risk factor and underscores the importance of comprehensive diagnostic workups. Treatment options are tailored to individual cases given the rarity and this report highlights the importance of careful diagnosis and management of uncommon metastatic patterns.<\/jats:p>","DOI":"10.1136\/bcr-2024-263235","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:55:17Z","timestamp":1779195317000},"page":"e263235","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Diffuse thyroid metastasis from oropharyngeal squamous cell carcinoma"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5431-4676","authenticated-orcid":false,"given":"Aymen","family":"Bahsoun","sequence":"first","affiliation":[{"name":"Radiology, University of Michigan Michigan Medicine, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3315-1879","authenticated-orcid":false,"given":"Aziz","family":"Farhat","sequence":"additional","affiliation":[{"name":"Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Issa","sequence":"additional","affiliation":[{"name":"University of Michigan-Ann Arbor, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadi F","family":"Azar","sequence":"additional","affiliation":[{"name":"University of Michigan Medical School, Ann Arbor, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"2026051905550896000_19.5.e263235.1","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/his.14246","article-title":"Metastasis to the thyroid gland: a single-institution 16-year experience","volume":"78","author":"Ghossein","year":"2021","journal-title":"Histopathology"},{"key":"2026051905550896000_19.5.e263235.2","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1365-2265.2007.02773.x","article-title":"Metastases to the thyroid gland: prevalence, clinicopathological aspects and prognosis: a 10-year experience","volume":"66","author":"Papi","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2026051905550896000_19.5.e263235.3","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.bjoms.2019.05.012","article-title":"Metastasis of squamous cell carcinoma of the head and neck to the thyroid: a single institution\u2019s experience with a review of relevant publications","volume":"57","author":"Vatsyayan","year":"2019","journal-title":"Br J Oral Maxillofac Surg"},{"key":"2026051905550896000_19.5.e263235.4","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1507\/endocrj.EJ17-0553","article-title":"A case report of thyroid metastasis from p16-positive oropharyngeal squamous cell carcinoma","volume":"65","author":"Takenobu","year":"2018","journal-title":"Endocr J"},{"key":"2026051905550896000_19.5.e263235.5","doi-asserted-by":"publisher","DOI":"10.2152\/jmi.67.189"},{"key":"2026051905550896000_19.5.e263235.6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.1713"},{"key":"2026051905550896000_19.5.e263235.7","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6733a2"},{"key":"2026051905550896000_19.5.e263235.8","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1001\/jamaoto.2021.3567","article-title":"Oropharyngeal Cancer Incidence and Mortality Trends in All 50 States in the US, 2001-2017","volume":"148","author":"Damgacioglu","year":"2022","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"2026051905550896000_19.5.e263235.9","first-page":"1427","article-title":"Oral cancer -diagnosis and therapy-","volume":"27","author":"Shibahara","year":"2017","journal-title":"Clin Calcium"},{"key":"2026051905550896000_19.5.e263235.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.12.019"},{"key":"2026051905550896000_19.5.e263235.11","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.22941.1","article-title":"Oral squamous cell carcinoma: metastasis, potentially associated malignant disorders, etiology and recent advancements in diagnosis","volume":"9","author":"Bugshan","year":"2020","journal-title":"F1000Res"},{"key":"2026051905550896000_19.5.e263235.12","doi-asserted-by":"crossref","unstructured":"Walker H , Speers J , Fabry M , et al . Metastatic oropharyngeal squamous cell carcinoma to the thyroid: A case report and review of literature. Am J Otolaryngol 2024;45. doi:10.1016\/j.amjoto.2024.104306","DOI":"10.1016\/j.amjoto.2024.104306"},{"key":"2026051905550896000_19.5.e263235.13","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1245\/s10434-016-5683-4","article-title":"Metastasis to the Thyroid Gland: A Critical Review","volume":"24","author":"Nixon","year":"2017","journal-title":"Ann Surg Oncol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-263235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:55:20Z","timestamp":1779195320000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-263235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":13,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5,19]]},"published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1136\/bcr-2024-263235"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-263235","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]}}}