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Laboratory data was significant for a prolonged activated partial thromboplastin time (aPTT) of 55\u2009s which prompted a haematology consult. A further work-up revealed the presence of an acquired FVIII inhibitor correlating with a severely reduced activity level. Treatment was given to eradicate the inhibitor with steroids and cyclophosphamide, while a thorough investigation was initiated for possible causes. Prompt recognition of an acquired inhibitor is essential for timely management to control bleeding.<\/jats:p>","DOI":"10.1136\/bcr-2024-263299","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T18:40:26Z","timestamp":1741200026000},"page":"e263299","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Acquired haemophilia A following COVID-19 vaccine"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1967-3662","authenticated-orcid":false,"given":"Jennifer Kate","family":"Beckerman","sequence":"first","affiliation":[{"name":"Hematology-Oncology, The George Washington University Hospital, Washington DC, District of Columbia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5541-3182","authenticated-orcid":false,"given":"Omar","family":"Yaghi","sequence":"additional","affiliation":[{"name":"Internal 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