{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T18:33:25Z","timestamp":1775327605541,"version":"3.50.1"},"reference-count":10,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2024,12,2]]},"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>Plasmablastic myeloma is a rare subtype of multiple myeloma, accounting for 5\u201310% of all cases, associated with poorer survival rates than typical multiple myeloma. This case report presents a man with plasmablastic myeloma with a previous history of diffuse large B-cell lymphoma which was in remission. He presented with paraplegia due to spinal cord compression and severe weakness. Investigations revealed abnormal immunoglobulin levels, hypercalcaemia and 80\u201390%\u2009bone marrow infiltration by plasmablasts. MRI revealed multiple spinal metastases and an incidental 6.1\u2009cm abdominal aortic aneurysm. Treatment given involved radiotherapy, three rounds of chemotherapy and physiotherapy. The patient showed improvement after radiotherapy, though some spinal lesions still remained. Key challenges included differentiating plasmablastic myeloma from plasmablastic lymphoma due to the history of diffuse large B-cell lymphoma as well as balancing treatment risks from concurrent health issues.<\/jats:p>","DOI":"10.1136\/bcr-2024-263511","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T12:25:30Z","timestamp":1734697530000},"page":"e263511","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Plasmablastic myeloma with a history of diffuse large B-cell lymphoma"],"prefix":"10.1136","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1030-9450","authenticated-orcid":false,"given":"Rachel Sooyon","family":"Lee","sequence":"first","affiliation":[{"name":"Geriatrics, Broomfield Hospital, Chelmsford, UK"},{"name":"Medicine, Barts and The London School of Medicine and Dentistry, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunaina","family":"Lohano","sequence":"additional","affiliation":[{"name":"Geriatrics, Broomfield Hospital, Chelmsford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Safdar","sequence":"additional","affiliation":[{"name":"Geriatrics, Broomfield Hospital, Chelmsford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"2025082722344379000_17.12.e263511.1","doi-asserted-by":"crossref","first-page":"e240998","DOI":"10.1136\/bcr-2020-240998","article-title":"Rare case of plasmablastic myeloma diagnosed on lung biopsy","volume":"14","author":"Ayeboa-Sallah","year":"2021","journal-title":"BMJ Case Rep"},{"key":"2025082722344379000_17.12.e263511.2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1182\/blood.V65.2.305.305","article-title":"Multiple myeloma: significance of plasmablastic subtype in morphological classification","volume":"65","author":"Greipp","year":"1985","journal-title":"Blood"},{"key":"2025082722344379000_17.12.e263511.3","unstructured":"Cleveland Clinic . Multiple myeloma: symptoms, what it is, prognosis & treatment. Cleveland Clinic; 2022. Available: https:\/\/my.clevelandclinic.org\/health\/diseases\/6178-multiple-myeloma"},{"key":"2025082722344379000_17.12.e263511.4","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijrobp.2017.06.1642","article-title":"Spinal Involvement in Myeloma: Incidence, Survival, and Impact of Radiotherapy","volume":"99","author":"Sharma","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2025082722344379000_17.12.e263511.5","doi-asserted-by":"crossref","first-page":"103205","DOI":"10.1016\/j.critrevonc.2020.103205","article-title":"Management of acute spinal cord compression in multiple myeloma","volume":"160","author":"Chen","year":"2021","journal-title":"Crit Rev Oncol Hematol"},{"key":"2025082722344379000_17.12.e263511.6","unstructured":"Bhatt R , Naha K , Desai DS . Plasmablastic lymphoma. In: Statpearls. Treasure Island: StatPearls Publishing, 2024. Available: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK532975\/"},{"key":"2025082722344379000_17.12.e263511.7","unstructured":"Israel D . Plasmablastic myeloma: differentiating a high risk disease. Hematology.org; 2022. Available: https:\/\/imagebank.hematology.org\/image\/63924\/plasmablastic-myeloma-differentiating-a-high-risk-disease"},{"key":"2025082722344379000_17.12.e263511.8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-10-567479"},{"key":"2025082722344379000_17.12.e263511.9","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.1391"},{"key":"2025082722344379000_17.12.e263511.10","article-title":"A Case of Plasmablastic Multiple Myeloma With Extramedullary Disease Manifesting as a Myelomatous Pleural Effusion","volume":"14","author":"Mohamed Jiffry","year":"2022","journal-title":"Cureus"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-263511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T05:34:57Z","timestamp":1756359297000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-263511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":10,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12,20]]},"published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1136\/bcr-2024-263511"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-263511","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]}}}