{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T05:03:05Z","timestamp":1774933385357,"version":"3.50.1"},"reference-count":23,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,3,24]]},"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>Malignant struma ovarii (MSO) is a rare ovarian tumour. The co-occurrence of MSO and thyroid carcinoma is even rarer. There is no established treatment for these patients. We report a postmenopausal woman in her 60s who presented with left hip pain, increased urinary frequency and fatigue. Imaging showed a left adnexal cystic lesion 8.8\u2009cm in diameter and an incidental 12\u00d78\u2009mm right ovarian cyst. She underwent total laparoscopic hysterectomy and bilateral salpingo-oophorectomy, and findings were significant for bilateral stage IA MSO. The metastatic workup showed concurrent papillary thyroid carcinoma. She underwent total thyroidectomy with neck dissection and radioactive iodine (RAI) adjuvant therapy. While thyroid carcinoma management is more standardised, a literature review yielded a wide range of MSO treatments. Recent literature favours conservative management with unilateral salpingo-oophorectomy. RAI therapy in these cases is controversial. We will discuss the literature findings on the optimal treatment of MSO with concurrent thyroid cancer.<\/jats:p>","DOI":"10.1136\/bcr-2024-263514","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T16:30:17Z","timestamp":1744129817000},"page":"e263514","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Bilateral malignant struma ovarii with concurrent thyroid carcinoma"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3586-2355","authenticated-orcid":false,"given":"Gwendolyn","family":"Glatz","sequence":"first","affiliation":[{"name":"Medical School, Hackensack Meridian Jersey Shore University Medical Center, Neptune, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Lann","sequence":"additional","affiliation":[{"name":"Endocrinology, Hackensack Meridian Jersey Shore University Medical Center, Neptune, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pritinder","family":"Thind","sequence":"additional","affiliation":[{"name":"Radiology, Hackensack Meridian Jersey Shore University Medical Center, Neptune, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3182-0808","authenticated-orcid":false,"given":"Karim","family":"ElSahwi","sequence":"additional","affiliation":[{"name":"Gynecology Oncology, Hackensack Meridian Jersey Shore University Medical Center, Neptune, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"2025082803324994000_18.4.e263514.1","doi-asserted-by":"crossref","first-page":"107318","DOI":"10.1016\/j.ijscr.2022.107318","article-title":"Struma ovarii: A case report and review the literature","volume":"96","author":"Zamani","year":"2022","journal-title":"Int J Surg Case Rep"},{"key":"2025082803324994000_18.4.e263514.2","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1080\/09513590.2021.1963953","article-title":"Hyperthyroidism associated with struma ovarii - a case report and review of literature","volume":"37","author":"Podfigurna","year":"2021","journal-title":"Gynecol Endocrinol"},{"key":"2025082803324994000_18.4.e263514.3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.11622\/smedj.2015007","article-title":"Struma ovarii: management and follow-up of a rare ovarian tumour","volume":"56","author":"Wee","year":"2015","journal-title":"Singapore Med J"},{"key":"2025082803324994000_18.4.e263514.4","doi-asserted-by":"crossref","first-page":"645156","DOI":"10.3389\/fonc.2021.645156","article-title":"The Clinical and Pathological Characteristics of Malignant Struma Ovarii: An Analysis of 144 Published Patients","volume":"11","author":"Cui","year":"2021","journal-title":"Front Oncol"},{"key":"2025082803324994000_18.4.e263514.5","unstructured":"Robboy SJ , R.Krigman H , Donohue J , et al . Prognostic indices in malignant struma ovarii: clinicopathologic analysis of 36 patients with 20+ year follow-up. Mod Pathol 1995;8."},{"key":"2025082803324994000_18.4.e263514.6","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3892\/ol.2024.14307","article-title":"Malignant struma ovarii with synchronous primary papillary thyroid cancer in the neck: A case report and literature review","volume":"27","author":"Li","year":"2024","journal-title":"Oncol Lett"},{"key":"2025082803324994000_18.4.e263514.7","unstructured":"National comprehensive cancer network . NCCN guidelines version 4.2024 thyroid carcinoma - papillary carcinoma. 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