{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T02:39:06Z","timestamp":1763001546818,"version":"3.45.0"},"reference-count":10,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,10,16]]},"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>Our report details an unusual case of chondrosarcoma in a man in his late 50s who presented with symptoms of pain, swelling and trismus. He was initially diagnosed with temporomandibular joint disorder (TMD) and managed conservatively. With time, symptoms progressed, so a cone beam CT scan was advised. The scan revealed an expansile lytic lesion in the condylar region with cortical erosion. It showed heterogeneous density with ring arch calcification around the condylar head, which was suggestive of the cartilaginous lesion. Microscopic examination showed a tumour composed of lobules of atypical chondrocytes with increased cellularity and hyperchromatic nuclei infiltrating the surrounding fibrous tissue. A confirmed diagnosis of grade I chondrosarcoma was made. The patient underwent surgical resection of the tumour with wide, clear margins. Follow-up care involved regular monitoring for any potential recurrence. This case highlights the rarity of chondrosarcoma, which presents with no specific symptoms or signs that can lead to a delay in diagnosis.<\/jats:p>","DOI":"10.1136\/bcr-2024-263577","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T02:35:11Z","timestamp":1763001311000},"page":"e263577","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Chondrosarcoma of the mandibular condyle"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8847-9372","authenticated-orcid":false,"given":"Sreelatha S","family":"V","sequence":"first","affiliation":[{"name":"Department of Oral & Maxillofacial Pathology and Oral Microbiology, Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Mangaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Padmaraj","family":"Hegde","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Nitte (Deemed to be University,) AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Mangaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yashi","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Pathology and Oral Microbiology, Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Mangaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soham","family":"Lahiri","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Nitte (Deemed to be University,) AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Mangaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"2025111218350793000_18.11.e263577.1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2005.46.2.228"},{"key":"2025111218350793000_18.11.e263577.2","doi-asserted-by":"crossref","unstructured":"Yibulayin F , Yu C , Feng L , et al . Malignant tumours of temporomandibular joint. BMC Cancer 2020;20. doi:10.1186\/s12885-020-07425-9","DOI":"10.1186\/s12885-020-07425-9"},{"key":"2025111218350793000_18.11.e263577.3","unstructured":"Limaiem F , Davis DD , Sticco KL . Chondrosarcoma. In: Statpearls. Treasure Island (FL): StatPearls Publishing, 2024."},{"key":"2025111218350793000_18.11.e263577.4","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-014-1685-4"},{"key":"2025111218350793000_18.11.e263577.5","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/CCO.0000000000000092","article-title":"Isocitrate dehydrogenase mutations in chondrosarcoma: the crossroads between cellular metabolism and oncogenesis","volume":"26","author":"Azzi","year":"2014","journal-title":"Curr Opin Oncol"},{"key":"2025111218350793000_18.11.e263577.6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40610-020-00126-z","article-title":"Is the IDH Mutation a Good Target for Chondrosarcoma Treatment?","volume":"6","author":"Cojocaru","year":"2020","journal-title":"Curr Mol Bio Rep"},{"key":"2025111218350793000_18.11.e263577.7","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.12688\/f1000research.15953.1","article-title":"Chondrosarcoma: biology, genetics, and epigenetics","volume":"7","author":"Chow","year":"2018","journal-title":"F1000Res"},{"key":"2025111218350793000_18.11.e263577.8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4103\/2231-0746.133076","article-title":"Central chondrosarcoma of a pediatric mandibular condyle: A case report and review","volume":"4","author":"Kumar Reddy","year":"2014","journal-title":"Ann Maxillofac Surg"},{"key":"2025111218350793000_18.11.e263577.9","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.1007\/s12070-021-02483-2","article-title":"A Case Report of Chondrosarcoma of Temporomandibular Joint","volume":"74","author":"Ampu","year":"2022","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"2025111218350793000_18.11.e263577.10","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s12105-021-01313-9","article-title":"Chondrosarcoma of the Temporomandibular Joint: Systematic Review and Survival Analysis of Cases Reported to Date","volume":"15","author":"Faro","year":"2021","journal-title":"Head and Neck Pathol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-263577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T02:35:12Z","timestamp":1763001312000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-263577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":10,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11,12]]},"published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1136\/bcr-2024-263577"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-263577","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]}}}