{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:10:07Z","timestamp":1756278607138,"version":"3.44.0"},"reference-count":10,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,3,20]]},"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>Phosphaturic mesenchymal tumours (PMTs) are rare neoplasms that secrete fibroblast growth factor 23 (FGF23), a hormone that disrupts phosphate homeostasis and induces tumour-induced osteomalacia (TIO). This condition causes hypophosphataemia, bone pain, fractures and musculoskeletal weakness. Due to the non-specific nature of these symptoms, TIO is often misdiagnosed with treatment delays. Surgical resection of PMTs is curative with rapid normalisation of serum phosphorus and full symptom resolution. PMTs are often located in the extremities and axial skeleton but can also occur in less common areas such as the intrathoracic region. We report a case of an intrathoracic PMT in a young woman who suffered for over 2 years without a diagnosis. The PMT was identified on CT, MRI and fluorodeoxyglucose-positron emission tomography and confirmed by histopathology. The tumour was excised via combined video-assisted thoracoscopic surgery and posterior thoracic resection. Within 6\u2009months, the patient experienced complete symptom resolution and normalised serum levels.<\/jats:p>","DOI":"10.1136\/bcr-2024-263622","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T03:45:34Z","timestamp":1747971934000},"page":"e263622","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Tumour-induced osteomalacia due to a rare intrathoracic phosphaturic mesenchymal tumour"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8256-860X","authenticated-orcid":false,"given":"Lauren Ka-Po","family":"Law","sequence":"first","affiliation":[{"name":"Medicine, Memorial University of Newfoundland Faculty of Medicine, St. John\u2019s, Newfoundland and Labrador, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"O\u2019Connell","sequence":"additional","affiliation":[{"name":"Pathology, Fraser Health Authority, Surrey, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Royal Columbian Hospital, New Westminster, British Columbia, Canada"},{"name":"Surgery, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3118-0646","authenticated-orcid":false,"given":"Sharon","family":"Ong","sequence":"additional","affiliation":[{"name":"Surgery, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada"},{"name":"Division of Thoracic Surgery, Surrey Memorial Hospital, Surrey, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"2025082623453272000_18.5.e263622.1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-11-0006"},{"key":"2025082623453272000_18.5.e263622.2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2019.07.002"},{"key":"2025082623453272000_18.5.e263622.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2006.12.062"},{"key":"2025082623453272000_18.5.e263622.4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.101545198"},{"key":"2025082623453272000_18.5.e263622.5","doi-asserted-by":"publisher","DOI":"10.4322\/acr.2017.031"},{"key":"2025082623453272000_18.5.e263622.6","doi-asserted-by":"crossref","first-page":"e1006","DOI":"10.1210\/clinem\/dgad690","article-title":"Clinical Characteristics of Malignant Phosphaturic Mesenchymal Tumor Causing Tumor-Induced Osteomalacia","volume":"109","author":"Abate","year":"2024","journal-title":"Clin Endocrinol Metab"},{"key":"2025082623453272000_18.5.e263622.7","doi-asserted-by":"crossref","DOI":"10.1186\/s12891-017-1756-1","article-title":"Treatment and outcomes of tumor-induced osteomalacia associated with phosphaturic mesenchymal tumors: retrospective review of 12 patients","volume":"18","author":"Zuo","year":"2017","journal-title":"BMC Musculoskelet Disord"},{"key":"2025082623453272000_18.5.e263622.8","first-page":"33","article-title":"Osteomalacia with Looser\u2019s nodes (Milkman\u2019s syndrome) due to a raised resistance to vitamin D acquired about the age of 15 years","volume":"16","author":"McCANCE","year":"1947","journal-title":"Q J Med"},{"key":"2025082623453272000_18.5.e263622.9","doi-asserted-by":"publisher","DOI":"10.1007\/s002560050581"},{"key":"2025082623453272000_18.5.e263622.10","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-018-3014-5"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-263622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:45:45Z","timestamp":1756277145000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-263622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":10,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5,22]]},"published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1136\/bcr-2024-263622"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-263622","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2025,5]]}}}