{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T23:23:26Z","timestamp":1769729006899,"version":"3.49.0"},"reference-count":32,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,2,10]]},"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>This report presents the case of a girl in early adolescence with symptoms suggestive of Papillon-Lef\u00e8vre syndrome (PLS) who remained undetected with poorly managed periodontitis until the advanced stage of alveolar resorption, leading to multiple tooth loss due to periodontitis. All remaining teeth had grade III mobility and negligible alveolar support, necessitating extraction. Conventional complete dentures were provided for functional and aesthetic rehabilitation. The literature review conducted to evaluate various dental treatment strategies and their outcomes for patients diagnosed with PLS at the deciduous or mixed dentition stage indicates that periodontal debridement with regular supportive periodontal therapy, antibiotic regimens and oral hygiene maintenance reinforcement can preserve teeth until late adolescence.<\/jats:p>","DOI":"10.1136\/bcr-2024-263958","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T23:55:28Z","timestamp":1740441328000},"page":"e263958","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Dental management of a young patient with Papillon-Lef\u00e8vre syndrome"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1829-2032","authenticated-orcid":false,"given":"Fakeha Azhar","family":"Syed","sequence":"first","affiliation":[{"name":"Surgery, Program of Prosthodontics, The Aga Khan University Hospital Main Campus Karachi, Karachi, Sindh, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamza","family":"Arshad","sequence":"additional","affiliation":[{"name":"Surgery, Program of Prosthodontics, The Aga Khan University Hospital Main Campus Karachi, Karachi, Sindh, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itrat","family":"Batool","sequence":"additional","affiliation":[{"name":"Surgery, Program of Operative Dentistry and Endodontics, The Aga Khan University Hospital Main Campus Karachi, Karachi, Sindh, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taimur","family":"Khalid","sequence":"additional","affiliation":[{"name":"Surgery, The Aga Khan University Hospital Main Campus Karachi, Karachi, Sindh, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"2025082711125770000_18.2.e263958.1","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/jdv.14834","article-title":"Hereditary palmoplantar keratodermas. 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