{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T18:09:42Z","timestamp":1762625382711,"version":"3.44.0"},"reference-count":9,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,4,11]]},"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>Drug-induced haemolytic anaemia (DIHA) is a rare and potentially life-threatening condition associated with various medications, including cephalosporins. DIHA can be either immune-mediated or non-immune-mediated, distinguishable through direct antiglobulin testing, also known as Coombs testing. Cephalexin has been implicated in both forms. Non-immune DIHA likely results from direct drug toxicity to erythrocytes, whereas immune-mediated DIHA, a type II hypersensitivity reaction, involves drug-dependent antibodies and\/or autoantibodies and is often triggered by penicillins, cephalosporins and non-steroidal anti-inflammatory drugs. We present a case of a woman in her late fifties who developed acute renal failure necessitating emergent haemodialysis following a single dose of cephalexin. She was subsequently diagnosed with cephalexin-induced autoimmune haemolytic anaemia. This case illustrates the importance of considering DIHA in patients presenting with renal failure and haemolytic anaemia.<\/jats:p>","DOI":"10.1136\/bcr-2024-263988","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T15:20:23Z","timestamp":1745335223000},"page":"e263988","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Cephalexin-induced haemolytic anaemia: a rare cause of acute renal failure requiring haemodialysis"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8826-268X","authenticated-orcid":false,"given":"Payton","family":"Markley","sequence":"first","affiliation":[{"name":"Medicine, The University of Kansas School of Medicine-Wichita, Wichita, Kansas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Moore","sequence":"additional","affiliation":[{"name":"Cancer Center of Kansas, Wichita, Kansas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salam","family":"Kadhem","sequence":"additional","affiliation":[{"name":"Kansas Nephrology Physicians, PA, Wichita, Kansas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Winchester","sequence":"additional","affiliation":[{"name":"Wesley Medical Center, Wichita, Kansas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Clawson","sequence":"additional","affiliation":[{"name":"Wesley Medical Center, Wichita, Kansas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"2025082723112859000_18.4.e263988.1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.tracli.2017.05.013","article-title":"Drug-induced hemolytic anemia: Pharmacological aspects","volume":"24","author":"Renard","year":"2017","journal-title":"Transfus Clin Biol"},{"key":"2025082723112859000_18.4.e263988.2","doi-asserted-by":"publisher","DOI":"10.1159\/000440673"},{"key":"2025082723112859000_18.4.e263988.3","unstructured":"Loscalzo J , Fauci AS , Kasper DL , eds. 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