{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:10:10Z","timestamp":1756275010289,"version":"3.44.0"},"reference-count":9,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,2,12]]},"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>This case report details a case of probable seronegative autoimmune encephalitis (AE) secondary to either an ovarian teratoma or a uterine smooth muscle tumour of uncertain malignant potential (STUMP). AE is a neurological disorder often associated with specific autoantibodies. However, cases can occur without identifiable antibodies, necessitating a broader diagnostic approach. We present a woman in her 30s who exhibited sudden-onset acute behavioural disturbance and psychiatric symptoms. Initial investigations, including both infective and autoimmune screening, returned negative. Further investigations revealed an adnexal mass and raised ovarian tumour markers. Both an ovarian teratoma and a uterine STUMP were resected. Postoperatively, the patient demonstrated significant clinical improvement, with resolution of neurological symptoms and normalisation of cognitive function.<\/jats:p>","DOI":"10.1136\/bcr-2024-264045","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T23:55:43Z","timestamp":1740441343000},"page":"e264045","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Seronegative autoimmune encephalitis associated with ovarian teratoma and uterine STUMP tumour"],"prefix":"10.1136","volume":"18","author":[{"given":"Christopher","family":"Niblock","sequence":"first","affiliation":[{"name":"Accident and Emergency, James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail","family":"Richards","sequence":"additional","affiliation":[{"name":"Accident and Emergency, James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damodar","family":"Makkuni","sequence":"additional","affiliation":[{"name":"Rheumatology Department, James Paget University Hospital, Norwich, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward James","family":"Needham","sequence":"additional","affiliation":[{"name":"Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"2025082622421420000_18.2.e264045.1","unstructured":"Autoimmune Encephalitis Alliance . Seronegative autoimmune encephalitis - Autoimmune Encephalitis Alliance. 2022. Available: https:\/\/aealliance.org\/ae-types\/seronegative-autoimmune-encephalitis\/"},{"key":"2025082622421420000_18.2.e264045.2","unstructured":"Gole S , Anand A . Autoimmune encephalitis. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2022. Available: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK578203\/"},{"key":"2025082622421420000_18.2.e264045.3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24076141","article-title":"Mature Cystic Teratoma: An Integrated Review","volume":"24","author":"Cong","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2025082622421420000_18.2.e264045.4","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70306-1"},{"key":"2025082622421420000_18.2.e264045.5","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.tjog.2019.03.004","article-title":"Anti-NMDAR encephalitis with ovarian teratomas: Review of the literature and two case reports","volume":"58","author":"Chiu","year":"2019","journal-title":"Taiwan J Obstet Gynecol"},{"key":"2025082622421420000_18.2.e264045.6","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70224-2"},{"key":"2025082622421420000_18.2.e264045.7","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.2169\/internalmedicine.0447-22","article-title":"Two Cases of Encephalitis without Anti-N-methyl-D-aspartate Receptor Antibody Successfully Treated with Ovarian Teratoma Resection and Immunotherapy","volume":"62","author":"Morooka","year":"2023","journal-title":"Intern Med"},{"key":"2025082622421420000_18.2.e264045.8","article-title":"Neurologic Presentation of Probable Seronegative Paraneoplastic Encephalitis in a Woman With an Ovarian Teratoma","volume":"12","author":"Chernyshkova","year":"2020","journal-title":"Cureus"},{"key":"2025082622421420000_18.2.e264045.9","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S1474-4422(23)00083-2","article-title":"Diagnostic criteria for autoimmune encephalitis: utility and pitfalls for antibody-negative disease","volume":"22","author":"Dalmau","year":"2023","journal-title":"Lancet Neurol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-264045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T05:42:26Z","timestamp":1756273346000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-264045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":9,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2,24]]},"published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1136\/bcr-2024-264045"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-264045","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2025,2]]}}}