{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:07:45Z","timestamp":1791277665538,"version":"4.1.0"},"reference-count":10,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,2,16]]},"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>Head and neck squamous cell carcinoma (HNSCC) with laryngeal involvement can lead to significant airway obstruction and compromise. This case report details a female patient in her 60s with a history of asthma who presented with refractory dyspnoea and persistent hoarseness, initially attributed to asthma. After multiple emergency room visits and treatment with bronchodilators and steroids, further investigation revealed an exophytic mass in the larynx, diagnosed as SCC. Despite normal pulmonary function tests, imaging indicated significant airway narrowing. The patient underwent a tracheostomy to secure her airway and was subsequently referred for curative surgery. This case underscores the importance of considering HNSCC in patients with unexplained respiratory symptoms, regardless of smoking history, and highlights the need for thorough investigation to prevent complications from advanced disease. Early multidisciplinary intervention is crucial in managing such cases effectively.<\/jats:p>","DOI":"10.1136\/bcr-2024-264064","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T23:55:42Z","timestamp":1740441342000},"page":"e264064","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Laryngeal squamous cell carcinoma disguised as asthma"],"prefix":"10.1136","volume":"18","author":[{"given":"Jason","family":"Corcoran","sequence":"first","affiliation":[{"name":"Alabama College of Osteopathic Medicine, Dothan, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6157-279X","authenticated-orcid":false,"given":"Ty","family":"Merry","sequence":"additional","affiliation":[{"name":"Internal Medicine, University of Florida College of Medicine, Jacksonville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0147-2774","authenticated-orcid":false,"given":"Kabeer","family":"Ali","sequence":"additional","affiliation":[{"name":"Internal Medicine, University of Florida College of Medicine, Jacksonville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod","family":"Reddy","sequence":"additional","affiliation":[{"name":"Internal Medicine, University of Florida College of Medicine, Jacksonville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"2025082713174568000_18.2.e264064.1","first-page":"42","article-title":"Epidemiology, Risk Factors, and Prevention of Head and Neck Squamous Cell Carcinoma","volume":"11","author":"Barsouk","year":"2023","journal-title":"Med Sci (Basel)"},{"key":"2025082713174568000_18.2.e264064.2","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s13193-020-01127-1","article-title":"The Association of Human Papillomavirus in Benign and Malignant Laryngeal Lesions-a Pilot Study","volume":"12","author":"George","year":"2021","journal-title":"Indian J Surg Oncol"},{"key":"2025082713174568000_18.2.e264064.3","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1007\/s00405-017-4718-1","article-title":"The role of high-risk human papillomavirus infections in laryngeal squamous cell carcinoma","volume":"274","author":"Wittekindt","year":"2017","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"2025082713174568000_18.2.e264064.4","first-page":"359","article-title":"A stepwise approach to the interpretation of pulmonary function tests","volume":"89","author":"Johnson","year":"2014","journal-title":"Am Fam Physician"},{"key":"2025082713174568000_18.2.e264064.5","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28588"},{"key":"2025082713174568000_18.2.e264064.6","article-title":"Management of an Acute Airway Obstruction Due to Tracheal Carcinoma in a Patient With Severe Glottic Stenosis","volume":"15","author":"Basiari","year":"2023","journal-title":"Cureus"},{"key":"2025082713174568000_18.2.e264064.7","doi-asserted-by":"crossref","first-page":"113S","DOI":"10.1177\/0145561320943354","article-title":"Case Report of Acute Airway Obstruction Caused by Transglottic Squamous Carcinoma (Stage IV) During the Coronavirus Pandemic Cured by ECMO-Assisted Tracheostomy","volume":"100","author":"Chen","year":"2021","journal-title":"Ear Nose Throat J"},{"key":"2025082713174568000_18.2.e264064.8","unstructured":"Nasir F , Anim-Koranteng C , Henry T , et al . Third time\u2019s a charm; a case of invasive squamous cell carcinoma of larynx causing recurrent respiratory failure. American Thoracic Society 2024 International Conference, May 17-22, 2024 - San Diego, CA; 2024 doi:10.1164\/ajrccm-conference.2024.209.1_MeetingAbstracts.A4654 Available: https:\/\/www.atsjournals.org\/doi\/book\/10.1164\/ajrccm-conference.2024.B80-7"},{"key":"2025082713174568000_18.2.e264064.9","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/oxfordjournals.annonc.a058213","article-title":"Steroid receptor status in malignant and non-malignant larynx","volume":"3","author":"Marsigliante","year":"1992","journal-title":"Ann Oncol"},{"key":"2025082713174568000_18.2.e264064.10","first-page":"S1","article-title":"Clinical Practice Guideline: Hoarseness (Dysphonia) (Update)","volume":"158","author":"Stachler","year":"2018","journal-title":"Otolaryngol--head neck surg"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-264064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T20:17:54Z","timestamp":1756325874000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-264064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":10,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2,24]]},"published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1136\/bcr-2024-264064"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-264064","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]}}}