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Erasmus syndrome is a rare condition characterised by the coexistence of SSc and silicosis and is often associated with prolonged occupational exposure to silica dust. It is important to note that these patients did not present with silicosis or interstitial lung disease, which has historically been associated with Erasmus syndrome. These cases highlight the importance of understanding SSc\u2019s potentially life-threatening aspects. It is associated with significant morbidity and mortality owing to multiorgan involvement. They also highlighted various clinical phenotypes of the disease, including serological tests and treatments.<\/jats:p>","DOI":"10.1136\/bcr-2024-264237","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T05:35:28Z","timestamp":1755668128000},"page":"e264237","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Three distinct presentations of systemic sclerosis in patients with previous silica dust exposure"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7762-3394","authenticated-orcid":false,"given":"David","family":"Landers","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Cork University Hospital, Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davida","family":"Hehir","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Cork University Hospital, Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gr\u00e1inne","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Cork University Hospital, Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"2025081922352399000_18.8.e264237.1","doi-asserted-by":"crossref","first-page":"102211","DOI":"10.1016\/j.coph.2022.102211","article-title":"Current advances in the treatment of systemic sclerosis","volume":"64","author":"Bukiri","year":"2022","journal-title":"Curr Opin Pharmacol"},{"key":"2025081922352399000_18.8.e264237.2","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.3390\/jcm11092299","article-title":"Systemic Scleroderma\u2014Definition, Clinical Picture and Laboratory Diagnostics","volume":"11","author":"Kowalska-K\u0119pczy\u0144ska","year":"2022","journal-title":"JCM"},{"key":"2025081922352399000_18.8.e264237.3","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1007\/s10067-018-4045-y","article-title":"High prevalence of occupational exposure to solvents or silica in male systemic sclerosis patients: a Belgian cohort analysis","volume":"37","author":"De Decker","year":"2018","journal-title":"Clin Rheumatol"},{"key":"2025081922352399000_18.8.e264237.4","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0140-6736(22)01692-0","article-title":"Systemic sclerosis","volume":"401","author":"Volkmann","year":"2023","journal-title":"The Lancet"},{"key":"2025081922352399000_18.8.e264237.5","doi-asserted-by":"publisher","DOI":"10.5114\/REUM.2019.87619"},{"key":"2025081922352399000_18.8.e264237.6","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1093\/rheumatology\/keab190","article-title":"Incidence and prevalence of systemic sclerosis globally: a comprehensive systematic review and meta-analysis","volume":"60","author":"Bairkdar","year":"2021","journal-title":"Rheumatology (Sunnyvale)"},{"key":"2025081922352399000_18.8.e264237.7","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s40744-023-00555-z","article-title":"Living with Systemic Sclerosis: A Patient and Physician Perspective","volume":"10","author":"Young","year":"2023","journal-title":"Rheumatol Ther"},{"key":"2025081922352399000_18.8.e264237.8","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.amsu.2022.104143","article-title":"Scleroderma and interstitial lung disease - 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