{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:40:02Z","timestamp":1756276802273,"version":"3.44.0"},"reference-count":7,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,4,2]]},"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal plasma cell disorder and Skin changes) syndrome is a rare paraneoplastic syndrome caused by a clone of aberrant plasma cells, mostly prevalent in middle-aged men. This is very rare, especially in women of reproductive age group. We are presenting a rare case of POEMS syndrome in pregnancy, who suffered from a full-blown picture of the multisystem involvement of hypothyroidism, hyperprolactinaemia, Empty Sella syndrome leading to panhypopituitarism and benign intracranial hypertension, peripheral neuropathy with trigeminal neuralgia and adrenal insufficiency. She was treated with autologous stem cell transplantation with adjuvant chemotherapy. This case report is a detailed description of the journey from in vitro fertilisation to delivery, the numerous challenges faced and how this was managed with the help of a multidisciplinary involvement to provide optimum perinatal outcome for the patient. Lack of any proper guideline about management of this rare syndrome in pregnancy made this more challenging.<\/jats:p>","DOI":"10.1136\/bcr-2024-264281","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T15:10:26Z","timestamp":1744816226000},"page":"e264281","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Successful assisted pregnancy outcome in a patient with POEMS syndrome"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5858-0392","authenticated-orcid":false,"given":"Abhishek","family":"Malakar","sequence":"first","affiliation":[{"name":"Obstetrics and Gynaecology, Hull Royal Infirmary, Hull, Yorkshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaazma Zainab","family":"Naqvi","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology, Lewisham and Greenwich NHS Trust, London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Tomkins","sequence":"additional","affiliation":[{"name":"Haematology, University College London Hospitals NHS Foundation Trust, London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukrutha","family":"Veerareddy","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology, Lewisham and Greenwich NHS Trust, London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Sive","sequence":"additional","affiliation":[{"name":"Haematology, University College London Hospitals NHS Foundation Trust, London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Lunn","sequence":"additional","affiliation":[{"name":"Neuromuscular, University College London Hospitals NHS Foundation Trust, London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley","family":"D\u2019Sa","sequence":"additional","affiliation":[{"name":"Haematology, University College London Hospitals NHS Foundation Trust, London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oseme","family":"Etomi","sequence":"additional","affiliation":[{"name":"Obstetric Medicine, Lewisham and Greenwich NHS Trust, London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"2025082623095010000_18.4.e264281.1","doi-asserted-by":"crossref","DOI":"10.1097\/HS9.0000000000000796","article-title":"Comprehensive Diagnosis and Management of POEMS Syndrome","volume":"6","author":"D\u2019Sa","year":"2022","journal-title":"Hemasphere"},{"doi-asserted-by":"crossref","unstructured":"Du HP , Zhang Y , Sun LM , et al . Two cases of special POEMS syndrome without monoclonal protein expression: a case report and literature review. J Int Med Res 2021;49. doi:10.1177\/0300060521990967","key":"2025082623095010000_18.4.e264281.2","DOI":"10.1177\/0300060521990967"},{"key":"2025082623095010000_18.4.e264281.3","first-page":"327","article-title":"Plasma-cell dyscrasia with polyneuropathy. The spectrum of POEMS syndrome","volume":"31","author":"Miralles","year":"1992","journal-title":"N Engl J Med"},{"unstructured":"Keddie S , et al . The natural history of POEMS syndrome: clinical characteristics, risk factors and outcomes, Available: https:\/\/discovery.ucl.ac.uk\/id\/eprint\/10103864\/3\/Brandner_013847-QUERY-MS.pdf","key":"2025082623095010000_18.4.e264281.4"},{"key":"2025082623095010000_18.4.e264281.5","article-title":"POEMS Syndrome: A Case Report and Review of the Literature","volume":"14","author":"Kanuganti","year":"2022","journal-title":"Cureus"},{"key":"2025082623095010000_18.4.e264281.6","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0029-7844(97)00222-6","article-title":"Castleman disease in pregnancy","volume":"90","author":"Abramov","year":"1997","journal-title":"Obstet Gynecol"},{"key":"2025082623095010000_18.4.e264281.7","doi-asserted-by":"crossref","first-page":"300","DOI":"10.4314\/mmj.v33i4.12","article-title":"A rare disease with pregnancy: Castleman case report","volume":"33","author":"Karaman","year":"2021","journal-title":"Malawi Med J"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-264281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:10:02Z","timestamp":1756275002000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-264281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":7,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4,16]]},"published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1136\/bcr-2024-264281"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-264281","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2025,4]]}}}