{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:19:17Z","timestamp":1788437957252,"version":"build-2803163510"},"reference-count":9,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,5,7]]},"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>Multiple endocrine neoplasia type 2B (MEN-2B) syndrome is a genetic disorder that predisposes to the development of tumours in the mouth, eyes and endocrine glands. It is associated with mucosal neuromas; however, laryngeal mucosal neuromas are very rare. We describe an adolescent with MEN-2B who presented with dysphonia, nocturnal stridor and exertional dyspnoea following a total thyroidectomy for an invasive medullary thyroid carcinoma with right recurrent laryngeal nerve sacrifice.<\/jats:p>\n                  <jats:p>Following initial assessment, laryngeal stroboscopy was performed, followed by a microlaryngobronchoscopy under general anaesthetic. A lesion was identified on the left vocal process that underwent debulking. Histopathological findings were consistent with mucosal neuromas.<\/jats:p>\n                  <jats:p>Laryngeal neuromas are rare in the context of MEN-2B and can pose significant diagnostic challenges, particularly in a patient with other airway pathologies. An awareness of different clinical features of MEN-2B is important to consider in differential diagnoses, and biopsy and histopathological analysis are essential for diagnostic purposes.<\/jats:p>","DOI":"10.1136\/bcr-2024-264356","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T12:30:11Z","timestamp":1779971411000},"page":"e264356","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Laryngeal neuroma in a MEN-2B paediatric patient"],"prefix":"10.1136","volume":"19","author":[{"given":"Mohammad","family":"Alsalem","sequence":"first","affiliation":[{"name":"Alder Hey Children\u2019s Hospital, Liverpool, Merseyside, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuwan","family":"Uthpali","sequence":"additional","affiliation":[{"name":"Paediatric ENT, Evelina London Children\u2019s Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4121-8762","authenticated-orcid":false,"given":"Christopher SG","family":"Thompson","sequence":"additional","affiliation":[{"name":"Alder Hey Children\u2019s Hospital, Liverpool, Merseyside, UK"},{"name":"Anatomy, University of Edinburgh Division of Health Sciences, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Possamai","sequence":"additional","affiliation":[{"name":"ENT, Evelina London Children\u2019s Hospital, London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"2026090305052502000_19.5.e264356.1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.33.9.779"},{"key":"2026090305052502000_19.5.e264356.2","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1007\/s001060170036","article-title":"Multilocular space-occupying endolaryngeal lesions. Mucosal neuromas of the glottis and supraglottis with in the scope of multiple endocrine neoplasia (MEN) type 2b","volume":"49","author":"Tolkemitt","year":"2001","journal-title":"HNO"},{"key":"2026090305052502000_19.5.e264356.3","first-page":"583","article-title":"A case of multiple endocrine neoplasia type 2B with laryngeal mucosal neuromatosis","volume":"79","author":"Inoue","year":"2007","journal-title":"Otolaryngol Head Neck Surg"},{"key":"2026090305052502000_19.5.e264356.4","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1017\/S0022215107000266","article-title":"Rare presentation of laryngeal neuroma in a patient with multiple endocrine neoplasia type two B","volume":"122","author":"Ghosh","year":"2008","journal-title":"J Laryngol Otol"},{"key":"2026090305052502000_19.5.e264356.5","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.anl.2013.12.007","article-title":"Laryngeal neuroma in multiple endocrine neoplasia type 2B","volume":"41","author":"Kudo","year":"2014","journal-title":"Auris Nasus Larynx"},{"key":"2026090305052502000_19.5.e264356.6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.otoeng.2014.05.011","article-title":"Multiple Mucosal Neuromas in the Larynx as Part of a Multiple Endocrine Neoplasia Type 2B","volume":"65","author":"Soroa-Ruiz","year":"2014","journal-title":"Acta Otorrinolaringologica (English Edition)"},{"key":"2026090305052502000_19.5.e264356.7","first-page":"E20","article-title":"Laryngeal neuromas in a case of multiple endocrine neoplasia type 2B","volume":"94","author":"McClurg","year":"2015","journal-title":"Ear Nose Throat J"},{"key":"2026090305052502000_19.5.e264356.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(05)80097-2"},{"key":"2026090305052502000_19.5.e264356.9","doi-asserted-by":"crossref","first-page":"368","DOI":"10.5794\/jjoms.53.368","article-title":"A case of multiple endocrine neoplasia type 2B diagnosed on the basis of multiple mucosal neuromas in the oral cavity","volume":"53","author":"Ata","year":"2007","journal-title":"Jpn J Oral Maxillofac Surg"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2024-264356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:05:32Z","timestamp":1788437132000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2024-264356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":9,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5,27]]},"published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1136\/bcr-2024-264356"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2024-264356","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]}}}